Assessing Causality of the Association Between Exercise and Neurocognitive Gains
NCT05511259, Not applicable, Completed, Nanyang Technological University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Assessing Causality of the Association Between Exercise and Neurocognitive Gains | ClinicalTrials.gov |
| NCT number | NCT05511259 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 93 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Nanyang Technological University | ClinicalTrials.gov |
| Conditions | Aging Well | ClinicalTrials.gov |
| Interventions | exercise | ClinicalTrials.gov |
| First posted | 2022-08-22 | ClinicalTrials.gov |
| Last updated | 2025-05-31 | ClinicalTrials.gov |
Registered outcomes 23
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Go-No-Go task change | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | Error rate: Number of "Go" responses on "No-Go" trials. | ClinicalTrials.gov |
| Primary | Stroop task colour words and colour blocks | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | Average response time (reaction time) for the correct colour word incongruent trials. | ClinicalTrials.gov |
| Primary | N-Back task change | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | Number of correct responses (hits) | ClinicalTrials.gov |
| Primary | Trail Making Test ((TMT) change | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | B:A: Divide the time taken for TMT B by TMT A | ClinicalTrials.gov |
| Primary | Digit Span task change | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | Maximum accurate span length for Digit Span Forward Maximum accurate span length for Digit Span Reverse | ClinicalTrials.gov |
| Primary | Modified Card Sorting task change | Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24) | Total number of perseverative errors | ClinicalTrials.gov |
| Primary | Static balance (single leg) change | Baseline (week 0), post-intervention (week 13 after session 24) | Duration required to perform single leg stance on left and right legs | ClinicalTrials.gov |
| Primary | Temporal gait parameters change | Baseline (week 0), post-intervention (week 13 after session 24) | 11-meter gait test to examine gait speed | ClinicalTrials.gov |
| Primary | Motor learning change | Baseline (week 0), post-intervention (week 13 after session 24) | Probabilistic Serial Reaction Time Task: learning index, computed using reaction time | ClinicalTrials.gov |
| Secondary | Change in cortical thickness | Baseline (week 0), post-intervention (week 13 after session 24) | T1 and T2 weighted images | ClinicalTrials.gov |
| Secondary | Change in grey matter volume | Baseline (week 0), post-intervention (week 13 after session 24) | T1 and T2 weighted images | ClinicalTrials.gov |
| Secondary | Change in structural topography | Baseline (week 0), post-intervention (week 13 after session 24) | T1 and T2 weighted images | ClinicalTrials.gov |
| Secondary | Change in white matter integrity | Baseline (week 0), post-intervention (week 13 after session 24) | Diffusion Tensor Imaging | ClinicalTrials.gov |
| Secondary | Change in white matter connectivity | Baseline (week 0), post-intervention (week 13 after session 24) | Diffusion Tensor Imaging | ClinicalTrials.gov |
| Secondary | Change in functional connectivity | Baseline (week 0), post-intervention (week 13 after session 24) | Resting state functional magnetic resonance imaging | ClinicalTrials.gov |
| Secondary | Brain plasticity changes | Baseline (week 0), post-intervention (week 13 after session 24) | Changes in transcranial magnetic stimulation (TMS) induced motor evoked potential amplitudes in response to theta-burst stimulation protocol | ClinicalTrials.gov |
| Secondary | Brain plasticity changes | Baseline (week 0), post-intervention (week 13 after session 24) | Changes in transcranial magnetic stimulation (TMS)-evoked potentials recorded from electroencephalography (EEG) | ClinicalTrials.gov |
| Secondary | Brain plasticity changes | Baseline (week 0), post-intervention (week 13 after session 24) | Changes in power spectral density and coherence recorded from electroencephalography (EEG) | ClinicalTrials.gov |
| Other | Subjective vitality scale change | Baseline (week 0), post-intervention (week 13 after session 24) | 5-item vitality score (7-point scale, higher score greater wellbeing outcome) | ClinicalTrials.gov |
| Other | Heart rate variability change | Baseline (week 0), post-intervention (week 13 after session 24) | Measured through deep breathing protocol with electrocardiography (ECG) | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 8
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Primary outcome | ConductCognition |
| 2-Back Task | Primary outcome | ConductCognition |
| Digit Span Test | Primary outcome | ConductCognition |
| Go/No-Go Task | Primary outcome | ConductCognition |
| Serial Reaction Time | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)