A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery
Trial · NCT05528172
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 12 of 12
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Central Corneal Endothelial Cell Density (ECD) at Week 12 | Baseline to Week 12 | Central corneal endothelial cell density (ECD) of the study eye, measured by specular microscopy, expressed as cells/mm². |
| Secondary | Change From Baseline in Central Corneal ECD at Each Visit | Baseline to Week 26 | Central corneal endothelial cell density (ECD) of the study eye, measured by specular microscopy, expressed as cells/mm². |
| Secondary | Change From Baseline in Peripheral Corneal ECD (Nasal) | Baseline to Week 26 | Peripheral corneal endothelial cell density (ECD) of the study eye, measured by specular microscopy, expressed as cells/mm². |
| Secondary | Change From Baseline in Peripheral Corneal ECD (Temporal) | Baseline to Week 26 | Corneal endothelial cell density (ECD) of the study eye, measured by specular microscopy, expressed as cells/mm². |
| Secondary | Change From Baseline in Central Corneal Thickness | Baseline to Week 26 | Corneal thickness measured by contact ultrasound pachymetry or optical pachymetry recorded in micrometers (μm) |
| Secondary | Number of Subjects With No Evidence of Corneal Edema | Baseline to Week 26 | Corneal edema of the study eye, evaluated by slit-lamp examination, recorded as present or absent, and categorized by anatomical location. |
| Secondary | Change From Baseline in Best-Corrected Visual Acuity (BCVA) | Baseline to Week 26 | Best-corrected visual acuity (BCVA) of the study eye, assessed using Early Treatment Diabetic Retinopathy Study (ETDRS) testing. |
| Secondary | Change From Baseline in VFQ-25 (Overall) | Baseline to Week 26 | Visual Function assessed using the National Eye Institute Visual Functioning Questionnaire-25 (VFQ-25), a patient-reported measure of vision-related functioning and quality of life. Scores range from 0 to 100, with higher scores indicating better visual function and lower scores indicating worse visual function. The total composite score is derived from multiple subscales using the standard VFQ-25 scoring method. |
| Secondary | Shifts in Slit-lamp Biomicroscopy (Bulbar Conjunctiva) | Baseline to Week 26 | Shift in slit-lamp biomicroscopy findings of the study eye categorized as Normal, Abnormal - Not Clinically Significant (NCS), or Abnormal - Clinically Significant (CS), reflecting changes relative to baseline. \- Baseline to Post-Baseline Shift |
| Secondary | Shifts in Slit-lamp Biomicroscopy (Cornea) | Baseline to Week 26 | Shift in slit-lamp biomicroscopy findings of the study eye, categorized as Normal, Abnormal - Not Clinically Significant (NCS), or Abnormal - Clinically Significant (CS), reflecting changes relative to baseline. Baseline to Post-Baseline Shift |
| Secondary | Shifts in Dilated Fundoscopy (Central Retina) | Baseline to Week 26 | Shift in dilated fundoscopy findings of the study eye, categorized as Normal, Abnormal - Not Clinically Significant (NCS), or Abnormal - Clinically Significant (CS), reflecting changes relative to baseline. Baseline to Post-Baseline Shift |
| Secondary | Change From Baseline in Intraocular Pressure (mmHg) | Baseline to Week 26 | Intraocular pressure (IOP) of the study eye, measured using either a contact or non-contact tonometer, and recorded in millimeters of mercury (mm Hg). |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/trials/v1/NCT05528172/registered