Trial · NCT05530252
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
NCT05530252, Phase 4, Completed, Beijing Stomatological Hospital, Capital Medical University; results first posted 2024-04-30
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis. Trials, record NCT05530252. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05530252
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
- NCT number
- NCT05530252
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 51 participants, actual
- Lead sponsor
- Beijing Stomatological Hospital, Capital Medical University
- Conditions
- Periodontitis
- Interventions
- Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP
- First posted
- 2022-09-07
- Last updated
- 2024-04-30
- Results first posted
- 2024-04-30
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Periodontal Probing Depth | Change from Baseline Periodontal probing depth at 90 days | from the gingival margin to the bottom of the periodontal pocket were assessed using a Williams periodontal probe((Hu-Friedy) |
| Primary | Attachment Level Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) | Change from Baseline Attachment level at 90 days | from the cementoenamel junction, crown margin or restoration to the bottom of the pocket |
| Primary | Bleeding Index Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) ,the Rating Method Was Assessed Using the Criteria of Mazza. | Change from Bleeding index at 90 days | Bleeding index : 0 = normal appearance of the gingiva and no bleeding on sulcus probing. 1. = normal appearance of the gingiva but bleeding on probing of the sulcus. 2. = bleeding on probing and gingival color change without swelling. 3. = bleeding on probing, gingival color change with mild swelling. 4. = bleeding on probing with marked gingival swelling, with or without color change. 5. = bleeding on probing, L Spontaneous bleeding, gingival color change with marked swelling, with or without ulceration. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Periodontal Probing Depth | Change from Baseline Periodontal probing depth at 90 days | Three subjects did not return to the clinic as required and were not included in the final data analysis of the study | millimeter | MEAN |
| PRIMARY | Attachment Level Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) | Change from Baseline Attachment level at 90 days | Three subjects did not return to the clinic as required and were not included in the final data analysis of the study | millimeter | MEAN |
| PRIMARY | Bleeding Index Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) ,the Rating Method Was Assessed Using the Criteria of Mazza. | Change from Bleeding index at 90 days | Three subjects did not return to the clinic as required and were not included in the final data analysis of the study | score on a scale | MEAN |
Source ClinicalTrials.gov
Results by group9
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Periodontal Probing Depth | AMP Group | 2.5 | Inter-Quartile Range 2.4 to 2.6 | millimeter | |
| Periodontal Probing Depth | Perio Group | 3.2 | Inter-Quartile Range 3.1 to 3.3 | millimeter | |
| Periodontal Probing Depth | SRP Group | 3.4 | Inter-Quartile Range 3.3 to 3.4 | millimeter | |
| Attachment Level Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) | AMP Group | 1.0 | Inter-Quartile Range 0.9 to 1 | millimeter | |
| Attachment Level Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) | Perio Group | 1.7 | Inter-Quartile Range 1.5 to 1.9 | millimeter | |
| Attachment Level Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) | SRP Group | 2.0 | Inter-Quartile Range 1.7 to 2.2 | millimeter | |
| Bleeding Index Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) ,the Rating Method Was Assessed Using the Criteria of Mazza. | AMP Group | 0.7 | Inter-Quartile Range 0.6 to 0.9 | score on a scale | |
| Bleeding Index Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) ,the Rating Method Was Assessed Using the Criteria of Mazza. | Perio Group | 1.1 | Inter-Quartile Range 1.0 to 1.3 | score on a scale | |
| Bleeding Index Were Assessed Using a Williams Periodontal Probe((Hu-Friedy) ,the Rating Method Was Assessed Using the Criteria of Mazza. | SRP Group | 1.3 | Inter-Quartile Range 1.2 to 1.4 | score on a scale |
Source ClinicalTrials.gov
Participant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | AMP Group | 17 | |
| Overall Study | STARTED | Perio Group | 17 | |
| Overall Study | STARTED | SRP Group | 17 | |
| Overall Study | COMPLETED | AMP Group | 16 | |
| Overall Study | COMPLETED | Perio Group | 16 | |
| Overall Study | COMPLETED | SRP Group | 16 | |
| Overall Study | NOT COMPLETED | AMP Group | 1 | |
| Overall Study | NOT COMPLETED | Perio Group | 1 | |
| Overall Study | NOT COMPLETED | SRP Group | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | AMP Group | 0 | 17 |
| Total, all-cause mortality | Perio Group | 0 | 17 |
| Total, all-cause mortality | SRP Group | 0 | 17 |
| Total, other adverse events | AMP Group | 0 | 17 |
| Total, other adverse events | Perio Group | 0 | 17 |
| Total, other adverse events | SRP Group | 0 | 17 |
| Total, serious adverse events | AMP Group | 0 | 17 |
| Total, serious adverse events | Perio Group | 0 | 17 |
| Total, serious adverse events | SRP Group | 0 | 17 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05530252
GET https://conductscience.org/api/trials/v1/NCT05530252/registered