Defining Neurobiological Links Between Substance Use and Mental Illness
NCT05538910, Not applicable, Recruiting, National Institute on Drug Abuse (NIDA)
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Defining Neurobiological Links Between Substance Use and Mental Illness | ClinicalTrials.gov |
| NCT number | NCT05538910 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 620 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | National Institute on Drug Abuse (NIDA) | ClinicalTrials.gov |
| Conditions | Major Depressive Disorder, Substance Use Disorder, Normal Physiology | ClinicalTrials.gov |
| Interventions | Placebo Nicotine Patch, Nicotine Patch | ClinicalTrials.gov |
| First posted | 2022-09-14 | ClinicalTrials.gov |
| Last updated | 2026-11-03 | ClinicalTrials.gov |
Registered outcomes 5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | 4.Nicotine effects and symptoms of MDD | At each scan visit | Greater expression of MDD symptoms will related to a larger nicotine-induced impact within that domain. | ClinicalTrials.gov |
| Primary | 3. Task and Resting State Brain | At each scan visit | Relate static and temporal dynamic resting state brain function to nicotinic effects. | ClinicalTrials.gov |
| Primary | 2.Task-fMRI | At each scan visit | 2\. Evaluate nicotine agonism on: 1) different phases of reward processing, 2) brain/behavioral measures of attentional bias using the classic and emotional Stroop task, and 1.3. 3) interoceptive awareness. 4) confidence on value-based decisions, determine the influence of sex in the context of points 1-3. | ClinicalTrials.gov |
| Primary | 1.Resting-fMRI | At each scan visit | 1.Determine the impact of nicotine agonism on the brain s inherent function and organization at rest. | ClinicalTrials.gov |
| Secondary | Determine the relationship between blood-based biomarkers, such as inflammatory makers/metabolomics and nicotinic effects | Ongoing | Correlate levels of blood-based biomarkers with brain and behavioral measures and determine whether nicotine... | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Emotional Stroop Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.