Trial · NCT05552976
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 16 of 16
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Progression-free Survival (PFS) | Up to approximately 5 years | |
| Secondary | Recommended Mezigdomide Dose | Up to 12 months | Stage 1 only |
| Secondary | Plasma concentrations of Mezigdomide in Combination with Carfilzomib and Dexamethasone | Up to 176 days | Stage 1 only |
| Secondary | Overall Survival (OS) | Up to approximately 5 years | |
| Secondary | Overall Response (OR) | Up to approximately 5 years | |
| Secondary | Rate Of Very Good Partial Response (VGPR) Or Better (VGPRR) | Up to approximately 5 years | VGPRR will be calculated as the percentage of participants who achieve best response of VGPR or better according to the International Myeloma Working Group (IMWG) Uniform Response Criteria for Multiple Myeloma. |
| Secondary | Complete Response (CR) Or Better (CRR) | Up to approximately 5 years | CRR will be calculated as the percentage of participants who achieve best response of CR or better according to the IMWG Uniform Response Criteria for Multiple Myeloma. |
| Secondary | Time To Response (TTR) | Up to approximately 5 years | |
| Secondary | Duration Of Response (DOR) | Up to approximately 5 years | |
| Secondary | Time To Progression (TTP) | Up to approximately 5 years | |
| Secondary | Time To Next Treatment (TTNT) | Up to approximately 5 years | |
| Secondary | Progression-free Survival 2 (PFS-2) | Up to approximately 5 years | |
| Secondary | Minimal Residual Disease (MRD) Negativity Rate | Up to approximately 5 years | |
| Secondary | Number Of Participants With Adverse Events (AEs) | Up to approximately 5 years | |
| Secondary | Change From Baseline in the European Organization for Research and Treatment of Cancer - Quality of Life C30 Questionnaire (EORTC QLQ-C30) | Up to approximately 5 years | The EORTC QLQ-C30 is the most commonly used quality of life instrument in oncology trials. The QLQ-C30 consists of 30 questions incorporated into 5 functional domains physical, role, cognitive, emotional, and social), 9 symptom/other scales (fatigue, pain, nausea and vomiting, dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties), and a single global Quality of Life (QoL)/global health status score. Items in the functional and symptom scale use raw participant response of 1 to 4, where 1 = "not at all" and 4 = "very much." The 2 global items contain responses ranging from 1 "very poor" to 7 "excellent." The recall period is 1 week. All domain scores are transformed in a range from 0 to 100, where a higher functional score indicates more favorable outcomes and a higher score on the symptom domains indicates a less favorable participant outcome. Stage 2 only. |
| Secondary | Change From Baseline in the European Quality of Life Multiple Myeloma Module (EORTC QLQ-MY20) | Up to approximately 5 years | The EORTC QLQ-MY20 is a 20-item myeloma module intended for use among participants varying in disease stage and treatment modality. Participants rate symptoms or problems on a scale from 1 to 4 where 1 = "not at all" and 4 = "very much." Stage 2 only. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
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GET https://conductscience.org/api/trials/v1/NCT05552976/registered