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Trial · NCT05570305

Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryChange from baseline in albuminuria after 4 weeks combined zibotentan and dapagliflozin treatment versus four weeks treatment with zibotentan alone.The albuminuria will be measured before start of medication intake and after the last intake of medication for each treatment period. This concerns a 4 week time frame.The change in albuminuria as expressed the percentage change of the log-transformed albumin:creatinine ratio in mg/gram. The log-transformation is because of the skewed distribution.
SecondaryChange in Extracellular Fluid4 weeksExtracellular Fluid measured by bioimpedance spectroscopy
SecondaryChange in bodyweight4 weeksChange in kilograms
SecondaryChange in NT-proBNP4 weeksN-terminal B-type natriuretic peptide (NT-proBNP)
SecondaryChange in BNP4 weeksB-type natriuretic peptide (BNP)
SecondaryChange in Glomerular Filtration Rate (GFR)4 weeksGlomerular Filtration Rate (GFR) using iohexol clearance techniques.
SecondaryChange in Extracellular volume (ECV)4 weeksExtracellular volume (ECV) using iohexol clearance techniques.
SecondaryChange in hematocrit4 weeksThe percentage of red blood cells in blood
SecondaryChange in systolic and diastolic blood pressure4 weeksChange in blood pressure as measure in mmHg
OtherChange in renin-angiotensin-aldosterone system (RAAS) markers4 weeksChange in RAAS markers in plasma and urine
OtherChange in copeptin4 weeksChange in copeptin as a surrogate of vasopressin

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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GET https://conductscience.org/api/trials/v1/NCT05570305/registered