Trial · NCT05589753
Sleep Disordered Breathing With Opioid Use
NCT05589753, Phase 1, Phase 2, Recruiting, VA Office of Research and Development
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Sleep Disordered Breathing With Opioid Use. Trials, record NCT05589753. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05589753
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Sleep Disordered Breathing With Opioid Use
- NCT number
- NCT05589753
- Status
- Recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 150 participants, estimated
- Lead sponsor
- VA Office of Research and Development
- Conditions
- Sleep Apnea, Opioid Use, Sleep Disordered Breathing
- Interventions
- Hyperoxia, Acetazolamide
- First posted
- 2022-10-21
- Last updated
- 2026-07-01
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Apneic threshold - a measure of breathing instability | 2 days to 30 days | Measures of breathing instability including: Apneic threshold: this is the end-tidal Co2 at which a central apnea closes to a hypopnea is produced. |
| Primary | Cerebrovascular responsiveness to carbon-dioxide | 7 days | Cerebrovascular response to different levels of CO2: this is a measure of the response of the cerebral blood flow to changes in carbon dioxide levels and is used as a measure of ventilatory control of breathing |
| Primary | Ventilatory responsiveness | 2 days to 30 days | Hypocapnic ventilatory response; this is calculated as the change in minute ventilation for corresponding changes in PETCO2. |
| Primary | Carbon-dioxide reserve | 2 days to 30 days | This is a derived measure. This is calculated as the difference between the apneic threshold PETCO2 (given above) and the control PETCO2. |
| Secondary | Apnea hypopnea index | 2 days to 30 days | Apnea hypopnea index- is a measure of severity of sleep apnea - this is calculated as the total number of apneas and hypopneas recorded during a sleep study divided by the total sleep time during the sleep study. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05589753
GET https://conductscience.org/api/trials/v1/NCT05589753/registered