Trial · NCT05593588
Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency
NCT05593588, Phase 2, Active not recruiting, Avni Joshi
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency. Trials, record NCT05593588. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05593588
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency
- NCT number
- NCT05593588
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 20 participants, estimated
- Lead sponsor
- Avni Joshi
- Conditions
- Common Variable Immunodeficiency, Interstitial Lung Disease Due to Systemic Disease
- Interventions
- Fisetin, Placebo
- First posted
- 2022-10-25
- Last updated
- 2026-06-30
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in immunophenotyping of peripheral T lymphocytes | Baseline, 6 months | Measured by percentage of activated CD4+25+ T cells |
| Secondary | Change in Forced Vital Capacity (FVC) | Baseline, 6 months | Measured by spirometry to determine the maximal amount of air that can be forcibly exhaled from the lungs after a full inhale, reported as liters (L) |
| Secondary | Change in radiologic imaging in subjects | Baseline, 3 months, 6 months | Number of subjects to have a 10% improvement with the CT scoring system. Radiologist will score the CT scans at each time point and changes in score at each time point will be noted. |
| Secondary | Use of MRI imaging for assessment of GLILD | 6 months | Number of MRI images that were used to assess for GLILD compared to High-resolution Computed Tomography (HRCT) use |
| Secondary | Infectious complications | 6 months | Number of subjects to experience infectious complications |
| Secondary | Adverse Events | 6 months | Number of adverse events reported |
| Secondary | Change in quality of life | Baseline, 6 months | Measured using the RAND 36-Short Form Survey Instrument (SF-36). The SF-36 Health Survey is a 36-item, participant-reported survey that measures patient health and disability. Possible scores range from 0 to 100, with 0 indicating maximum disability, and 100 indicating no disability |
| Secondary | Change in 6 minute walk test | Baseline, 6 months | Number of subjects to have a 10% improvement in 6 minute walk test. The 6 minute walk test measures the distance a person is able to walk in 6 minutes. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05593588
GET https://conductscience.org/api/trials/v1/NCT05593588/registered