Trial · NCT05609877
The NONA-LISA Trial
NCT05609877, Not applicable, Recruiting, Copenhagen University Hospital, Rigshospitalet
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The NONA-LISA Trial. Trials, record NCT05609877. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05609877
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The NONA-LISA Trial
- NCT number
- NCT05609877
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 324 participants, estimated
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Conditions
- Respiratory Distress Syndrome in Premature Infant
- Interventions
- Isotonic saline, Less Invasive Surfactant Administration (LISA), Fentanyl, Non-pharmacological standard operating procedure
- First posted
- 2022-11-08
- Last updated
- 2024-09-20
Source ClinicalTrials.gov
Registered outcomes28
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | LISA failure within 24 hours. | 24 hours after procedure. | The primary outcome will be LISA failure in terms of the need for endotracheal intubation and mechanical ventilation for at least 30 minutes (cumulated) within 24 hours after the procedure. |
| Secondary | Incidence of additional fentanyl administration | During the procedure, an average of 5-10 minutes. | This will include the number of injection(s), dosage, cumulated dose, and indications defined as pain/discomfort/sedation/other. |
| Secondary | Pain or discomfort during the procedure (according to COMFORTneo score >14). | 24 hours after procedure | This will include a numerical and a categorical variable (COMFORTneo score \>/\< 14). |
| Secondary | Bradycardia <100 BPM for a minimum duration of 4 seconds. | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Need for a second dose of surfactant | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Escalation from LISA to INSURE in the same attempt | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Apnoea that require bag and mask ventilation during the procedure | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Observed surfactant reflux | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Desaturation with SaO2 (right extremity measure) <85% during the procedure | 24 hours after procedure. | This is a categorical variable (yes/no). |
| Secondary | Procedural time consumption from the introduction of the laryngoscope blade into the oral cavity to removal of the catheter. | 24 hours after procedure. | This is a categorical variable (yes/no). |
1 to 10 of 28Source ClinicalTrials.gov
See all 28 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05609877
GET https://conductscience.org/api/trials/v1/NCT05609877/registered?page=2