Chronic Postsurgical Pain, Postoperative Cognitive Dysfunction and Resilience
NCT05614271, Unknown, McMaster University
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Chronic Postsurgical Pain, Postoperative Cognitive Dysfunction and Resilience | ClinicalTrials.gov |
| NCT number | NCT05614271 | ClinicalTrials.gov |
| Status | Unknown | ClinicalTrials.gov |
| Enrollment | 100 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | McMaster University | ClinicalTrials.gov |
| Conditions | Postoperative Cognitive Dysfunction, Chronic Post Operative Pain, Satisfaction, Patient, Coping Behavior | ClinicalTrials.gov |
| First posted | 2022-11-14 | ClinicalTrials.gov |
| Last updated | 2022-11-14 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Incidence of postoperative cognitive dysfunction (binary outcome) | 6 and 12 months postoperative | defined as a \>=2 point decline in MoCA scores. | ClinicalTrials.gov |
| Secondary | Changes in the Mnemonic Similarity Test scores | 4-6 weeks and 6 and 12 months | Participants are first engaged in an encoding phase then a subsequent recognition test with a 3-choice response; exact repetitions of earlier items, lures (similar but not identical to earlier items), and novel foils. During the test, participants are asked to identify each item as "Old," "Similar," or "New". The lure discrimination index (which measures mnemonic discrimination) is calculated as the difference between the rate of "Similar" responses given to the lure items minus "Similar" responses given to the foils. Typically, 'normal' aging is associated with a decline in mnemonic discrimination (identifying lure objects that are similar to memory set objects as "similar") with preserved recognition memory (identifying repeated memory set objects as "old"). The MST version used in the study is a validated modified online version of MST adapted to increase the efficiency of the test. | ClinicalTrials.gov |
| Secondary | Changes in the Visual Paired Associates Learning (PAL) test | 4-6 weeks and 6 and 12 months | A computer task that assesses visual memory and new learning by testing a participant's memory for object location pairs. Boxes are displayed on the screen and are opened in a randomized order. One or more of them will contain a pattern. The patterns are then displayed in the middle of the screen, one at a time, and the participant must touch the box where the pattern was originally located. If the participant makes an error, the patterns are represented by their locations. The difficulty increases throughout the test. The average accuracy across the last two completed levels will be analyzed | ClinicalTrials.gov |
| Secondary | Changes in the Rapid serial Visual Presentation (RVP) test | 4-6 weeks and 6 and 12 months | A white box is shown in the centre of the screen, inside which digits from 2 to 9 appear in a pseudo-random order, at the rate of 100 digits per minute. Participants are requested to detect target sequences of digits (for example, 2-4-6, 3-5-7, 4-6-8). When the participant sees the target sequence they must respond by selecting the button in the centre of the screen as quickly as possible. The level of difficulty varies with either one- or three-target sequences that the participant must watch for at the same time. The average accuracy throughout the task will be analyzed. | ClinicalTrials.gov |
| Secondary | Changes in the Stroop color word color interference task CWIT | 4-6 weeks and 6 and 12 months | CWIT has the standard color naming, word reading, and color-word interference trials,in addition to additional trial requiring the examinee to switch between inhibitory and non-inhibitory responses. Process measures enable assessment of general difficulties. Condition 1: Color Naming, Condition 2: Word Reading, Condition 3: Inhibition, Condition 4: Inhibition/ Switching requires adequate naming speed, reading speed, verbal inhibition, and cognitive flexibility.and Scores will include the time needed to complete each condition, the number of errors and the number of self-corrected errors | ClinicalTrials.gov |
| Secondary | Changes in the N-back test | 4-6 weeks and 6 and 12 months | Participants are shown a series of numbers on the screen and are asked to enter the number they saw two numbers ago. The outcome measures are correct detection and reaction times. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Secondary outcome | ConductCognition |
| 2-Back Task | Secondary outcome | ConductCognition |
| Mnemonic Similarity Task | Secondary outcome | ConductCognition |
| Paired Associate Learning | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)