Registered outcomes14

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 14 of 14

List	Outcome	Time frame	Description
Primary	Apnea Hypopnea Index	14 days	The AHI is a measure of sleep apnea severity and is defined as the number of apneas (no breathing for 10+ seconds) and hypopneas (reduced breathing for 10+ seconds associated with a \>=3% desaturation or cortical arousal) per hour of sleep.
Primary	24-hour Mean Blood Pressure	14 days	Based on 24h blood pressure measurements
Secondary	Hypoxic Burden	14 days	Respiratory event-associated area under the desaturation curve from pre-event baseline
Secondary	Reactive Hyperemia Index	14 days	Based on a device called EndoPAT, which measures non-invasively bloodflow before, during, and after 5-minutes of occlusion to one arm.
Secondary	Response Speed	14 days	Based on 10-minute Psychomotor vigilance task (PVT)
Secondary	Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance (SDA) instrument	14 days	Based on response pattern scoring, the PROMIS 8-item SDA score will be converted into a T-score with a mean of 50 (reflecting the average for the United States general population) and a standard deviation of 10. Higher t-scores reflect greater sleep disturbance.
Secondary	Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Related Impairment (SRI) instrument	14 days	Based on response pattern scoring, the PROMIS 8-item SRI score will be converted into a T-score with a mean of 50 (reflecting the average for the United States general population) and a standard deviation of 10. Higher t-scores reflect greater sleep-related impairment.
Secondary	Epworth Sleepiness Scale (ESS)	14 days	The ESS is an 8-item instrument assessing the likelihood of dozing off in 8 different situations with points for each item ranging from 0 to 3 (0 = would never doze off; 3 = high chance of dozing off). The points for each item are summed up, thus the total score ranges from 0 to 24, with higher ESS scores indicating greater sleepiness.
Secondary	24-hour Mean Systolic Blood Pressure	14 days	Based on 24h blood pressure measurements
Secondary	24-hour Mean Diastolic Blood Pressure	14 days	Based on 24h blood pressure measurements
Other	Measures of Heart-rate Variability	14 days	Based on 5 min awake, supine ECG sampled at \>250Hz
Other	Overnight Memory Improvement (%)	14 days	Based on Verbal Paired-Associates task
Other	Short Form 36 (SF-36) Health Survey	14 days	The SF36 is a widely used questionnaire to measure general health-related quality of life across 8 domains (e.g. physical functioning, Energy/fatigue, Social functioning, etc). The score for each of the 8 domains ranges from 0 to 100, with greater scores indicating better health-related quality fo life in this domain.
Other	Sleep Apnea Traits with special focus on loop gain	14 days	Quantified from routine polysomnography data.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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