Trial · NCT05638893
Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
NCT05638893, Phase 2, Phase 3, Completed, Tanta University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients. Trials, record NCT05638893. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05638893
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
- NCT number
- NCT05638893
- Status
- Completed
- Phases
- Phase 2, Phase 3
- Enrollment
- 50 participants, actual
- Lead sponsor
- Tanta University
- Conditions
- Knee Osteoarthritis
- Interventions
- Placebo Tablet, Metformin Hcl 500Mg Tab
- First posted
- 2022-12-06
- Last updated
- 2022-12-07
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Western Ontario and McMaster Universities Arthritis Index (WOMAC) | 12 weeks | Measure change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) at baseline and after 12weeks of treatment. |
| Primary | Weight (Kg) | 12 weeks | Measure change in weight in kilograms at baseline and after 12weeks of treatment. |
| Secondary | Cartilage Oligomeric Matrix Protein (COMP) | 12 weeks | Measure change in Cartilage Oligomeric Matrix Protein (COMP) serum level at baseline and after 12weeks of treatment. |
| Secondary | C-terminal crosslinked telopeptide of type I collagen (CTX-1) | 12 weeks | Measure change in C-terminal crosslinked telopeptide of type I collagen (CTX-1) serum level at baseline and after 12weeks of treatment. |
| Secondary | Interleukin 1-beta (IL-1β) | 12 weeks | Measure change in Interleukin 1-beta (IL-1β) serum level at baseline and after 12weeks of treatment. |
| Secondary | Adverse drug events | 12 weeks | side effects |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38869746 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05638893
GET https://conductscience.org/api/trials/v1/NCT05638893/registered