Trial · NCT05650333
Results by group54
Each measurement the trial posted, group by group, in the words and numbers it posted.
1 to 20 of 54
Download this page as JSON| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Area Under the Plasma Concentration-Time Profile Over the Dosing Interval of 24 Hours, at Steady State (AUC24ss/AUCtau) of Ritlecitinib on Day 7 | Ritlecitinib 20 mg | 437.5 | Geometric Coefficient of Variation 30 | Nanogram*hours per milliliter (ng*hr/mL) | |
| Maximum Observed Plasma Concentration (Cmax) of Ritlecitinib | Ritlecitinib 20 mg | 208.7 | Geometric Coefficient of Variation 38 | Nanogram per milliliter (ng/mL) | |
| Time to Reach Maximum Observed Plasma Concentration (Tmax) of Ritlecitinib | Ritlecitinib 20 mg | 0.500 | Full Range 0.450 | Hours | |
| Apparent Oral Clearance (CL/F) of Ritlecitinib | Ritlecitinib 20 mg | 45.70 | Geometric Coefficient of Variation 30 | Liter per hour (L/hr) | |
| Apparent Volume of Distribution (Vz/F) of Ritlecitinib | Ritlecitinib 20 mg | 74.92 | Geometric Coefficient of Variation 23 | Liter | |
| Elimination Half-Life (t1/2) of Ritlecitinib | Ritlecitinib 20 mg | 1.191 | Standard Deviation 0.10776 | Hours | |
| Change From Baseline in Interferon Gamma Induced Protein 10 (IP-10) on Day 7 | Ritlecitinib 20 mg | Baseline | 121.0 | Full Range 74.7 to 888.0 | Picogram per milliliter (pg/mL) |
| Change From Baseline in Interferon Gamma Induced Protein 10 (IP-10) on Day 7 | Ritlecitinib 20 mg | Change at Day 7 | -9.9 | Full Range -555.0 to 104.0 | Picogram per milliliter (pg/mL) |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD3 cells: Baseline | 1.8 | Full Range 0.8 to 3.4 | 10^9 cells per liter |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD3 cells: Change at Day 7 | -0.0 | Full Range -1.3 to 2.0 | 10^9 cells per liter |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD4 T helper lymphocytes: Baseline | 1.0 | Full Range 0.6 to 1.6 | 10^9 cells per liter |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD4 T helper lymphocytes: Change at Day 7 | -0.1 | Full Range -0.6 to 1.1 | 10^9 cells per liter |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD8 T cytotoxic lymphocytes: Baseline | 0.6 | Full Range 0.2 to 1.5 | 10^9 cells per liter |
| Change From Baseline in T Lymphocytes on Day 7 | Ritlecitinib 20 mg | CD8 T cytotoxic lymphocytes: Change at Day 7 | 0.0 | Full Range -0.6 to 0.8 | 10^9 cells per liter |
| Change From Baseline in B Lymphocytes on Day 7 | Ritlecitinib 20 mg | Baseline | 439.0 | Full Range 191.0 to 881.0 | 10^6 cells per liter |
| Change From Baseline in B Lymphocytes on Day 7 | Ritlecitinib 20 mg | Change at Day 7 | -19.0 | Full Range -116.0 to 766.0 | 10^6 cells per liter |
| Change From Baseline in Natural Killer (NK) Cells on Day 7 | Ritlecitinib 20 mg | Baseline | 254.0 | Full Range 85.0 to 729.0 | 10^6 cells per liter |
| Change From Baseline in Natural Killer (NK) Cells on Day 7 | Ritlecitinib 20 mg | Change at Day 7 | -25.5 | Full Range -318.0 to 627.0 | 10^6 cells per liter |
| Number of Participants With Treatment Emergent Adverse Events (TEAEs) | Ritlecitinib 20 mg | 3 | Participants | ||
| Number of Participants With Treatment Related AEs | Ritlecitinib 20 mg | 1 | Participants |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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