Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance
NCT05651243, Not applicable, Completed, University of Southern Mississippi
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance | ClinicalTrials.gov |
| NCT number | NCT05651243 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 20 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Southern Mississippi | ClinicalTrials.gov |
| Conditions | Metabolic Syndrome | ClinicalTrials.gov |
| Interventions | Ketone Ester Supplement, Placebo | ClinicalTrials.gov |
| First posted | 2022-12-14 | ClinicalTrials.gov |
| Last updated | 2024-05-22 | ClinicalTrials.gov |
Registered outcomes 34
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Blood pressure | Baseline (pre-ingestion) | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 30 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 45 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 60 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 75 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 90 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Blood pressure | 105 minutes post ingestion | Blood pressure responses (systolic and diastolic) to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | Baseline (pre-ingestion) | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 30 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 45 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 60 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 75 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 90 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate | 105 minutes post ingestion | Heart rate responses to sympathoexcitation | ClinicalTrials.gov |
| Primary | Heart Rate Variability | Baseline (pre-ingestion) | Index of cardiac autonomic control | ClinicalTrials.gov |
| Primary | Heart Rate Variability | 45 post ingestion | Index of cardiac autonomic control | ClinicalTrials.gov |
| Primary | Cardiac Baroreflex Sensitivity | 105 minutes post ingestion | Changes in cardiac interval relative to changes in systolic blood pressure | ClinicalTrials.gov |
| Primary | Hunger - Visual Digital Analog Scale (0-100) | Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion | Changes in subjective rating of hunger | ClinicalTrials.gov |
| Primary | Fullness - Visual Digital Analog Scale (0-100) | Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion | Changes in subjective rating of fullness | ClinicalTrials.gov |
| Primary | Desire to eat - Visual Digital Analog Scale (0-100) | Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion | Changes in subjective rating of desire to eat | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 40745496 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Primary outcome | ConductCognition |
| Go/No-Go Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Task Switching Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)