Acquiring and Targeting Heat Exposures Necessary for Action
NCT05678738, Not applicable, Completed, University of Connecticut
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Acquiring and Targeting Heat Exposures Necessary for Action | ClinicalTrials.gov |
| NCT number | NCT05678738 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 108 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Connecticut | ClinicalTrials.gov |
| Conditions | Heat Intolerance, Heat Stress, Fatigue; Heat | ClinicalTrials.gov |
| Interventions | Antioxidant Berry Supplementation, Acute and Chronic Exercise-Heat Stress, Placebo (non-juice) Supplementation | ClinicalTrials.gov |
| First posted | 2023-01-10 | ClinicalTrials.gov |
| Last updated | 2025-09-11 | ClinicalTrials.gov |
Registered outcomes 53
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Rectal Temperature at Rest | Through study completion, an average of 14 days | Rectal thermometer will be self-inserted by participants to assess core temperature prior to exercise-heat stress bouts | ClinicalTrials.gov |
| Primary | Change in Rectal Temperature Rate of Rise | Through study completion, an average of 14 days | Rectal thermometer will be self-inserted by participants to assess core temperature during exercise-heat stress bouts | ClinicalTrials.gov |
| Primary | Change in Rectal Temperature at Thermal Threshold (38.5C) | Measured throughout 5 90-minute exercise-heat stress bouts (heat acclimation sessions) | Rectal thermometer will be self-inserted by participants to assess core temperature during exercise-heat stress bouts at the thermal threshold of 38.5C | ClinicalTrials.gov |
| Primary | Change in Mean Skin Temperature | Through study completion, an average of 14 days | Prior to start of exercise, participants will be instrumented with iButton skin temperature sensors on the chest, shoulder, abdomen, neck, back, thigh, and calf | ClinicalTrials.gov |
| Primary | Change in Heart Rate | Through study completion, an average of 14 days | A heart rate monitor will be worn by participants throughout the exercise-heat stress bouts | ClinicalTrials.gov |
| Primary | Change in Heart Rate at Thermal Threshold (38.5C) | Measured throughout 5 90-minute exercise-heat stress bouts (heat acclimation sessions) | A heart rate monitor will be worn by participants throughout the exercise-heat stress bouts to assess HR at the thermal threshold of 38.5C | ClinicalTrials.gov |
| Primary | Change in Whole Body Sweat Rate | Measured at the beginning and end of 5 90-minute exercise-heat stress bouts (heat acclimation sessions) | Difference in body weight measurement measured prior to and at the cessation of each exercise-heat stress bout | ClinicalTrials.gov |
| Primary | Change in Sweat Metabolite and Protein Expression | Measurement completed during each exercise-heat stress bout (Heat Tolerance Tests 1 [days 5 and 12] and 2 [days 6 and 13]) both before and immediately after heat acclimation as well as the final heat acclimation session (HA5 - day 11) | Sweat samples will be collected and assessed for metabolite and protein expression discovery via mass spectrometry | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Visual Vigilance | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of visual vigilance through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Psychomotor Vigilance | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of psychomotor vigilance through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Four Choice Task | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of four choice task success through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Match to Sample | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of match to sample success through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Repeated Acquisition | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of repeated acquisition through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Grammatical Reasoning | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of grammatical reasoning through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Profile of Mood States | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of profile of mood states through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Cognitive Measures - Stroop Task | Measurement completed immediately after one exercise-heat stress bout (Heat Tolerance Test 2 - days 6 and 13) both before and immediately after heat acclimation | Participants will perform an assessment of stroop task success through a validated computer programming system. The test is part of a larger Testing battery which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Physical Performance - Anaerobic Performance | Measurements completed immediately after the cognitive battery performed during the Heat Tolerance Test 2 (days 6 and 13) both before and immediately after heat acclimation | Participants will be assessed for anaerobic performance with the completion of a 400 meter sprint for time. This test is part of a larger physical performance battery test which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Physical Performance - Agility Performance | Measurements completed immediately after the cognitive battery performed during the Heat Tolerance Test 2 (days 6 and 13) both before and immediately after heat acclimation | Participants will be assessed for anaerobic performance with the completion of a quick feet agility test. This test is part of a larger physical performance battery test which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Physical Performance - Upper Body Strength Performance | Measurements completed immediately after the cognitive battery performed during the Heat Tolerance Test 2 (days 6 and 13) both before and immediately after heat acclimation | Participants will be assessed for upper body strength performance with the completion of a handgrip strength test. This test is part of a larger physical performance battery test which should take approximately 30 minutes for completion | ClinicalTrials.gov |
| Primary | Change in Physical Performance - Lower Body Power Performance | Measurements completed immediately after the cognitive battery performed during the Heat Tolerance Test 2 (days 6 and 13) both before and immediately after heat acclimation | Participants will be assessed for lower body power performance with the completion of a vertical jump test. This test is part of a larger physical performance battery test which should take approximately 30 minutes for completion | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Psychomotor Vigilance Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)