Trial · NCT05683301
Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India
NCT05683301, Phase 4, Completed, Centre for Chronic Disease Control, India
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India. Trials, record NCT05683301. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05683301
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India
- NCT number
- NCT05683301
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 1,981 participants, actual
- Lead sponsor
- Centre for Chronic Disease Control, India
- Conditions
- Primary Hypertension
- Interventions
- Amlodipine + Perindopril, Perindopril + Indapamide, Amlodipine + Indapamide
- First posted
- 2023-01-13
- Last updated
- 2024-10-08
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | 24-hour ambulatory systolic Blood Pressure | Change in between baseline and 6 month Ambulatory Systolic Blood Pressure | To determine which of three single pill combinations of two anti-hypertensive agents is most effective in reducing 24-hour ambulatory systolic BP (ASBP) in Indian patients with hypertension. |
| Secondary | 24-hour ambulatory diastolic blood pressure | Change in between baseline and 6 month Ambulatory Diastolic Blood Pressure | To determine which of three single pill combinations of two antihypertensive agents is most effective in reducing 24-hour ambulatory diastolic blood pressure at 6 months adjusted for baseline ADBP |
| Secondary | Clinic Blood Pressure | Comparison of Clinic blood pressure measured at baseline 2 month , 4 month and 6 month | To determine which of three single pill combinations of two antihypertensive agents is most effective in reducing Clinic SBP and diastolic blood pressure (DBP) at two, four and six months adjusted for baseline values |
| Secondary | Daytime and nighttime Blood Pressure | Change in between baseline and 6 month ASBP and ADBP | To determine which of three single pill combinations of two antihypertensive agents is most effective in reducing Daytime and nighttime blood pressure (BP) a t six months adjusted for baseline values |
| Secondary | BP variability measured by ABPM and within-visit clinic BPs | Fluctuations in Ambulatory blood pressures as measured at baseline and 6 month and fluctuation in Clinic BP as measured at baseline, 2 month, 4 month and 6 month | To determine which of three single pill combinations of two antihypertensive agents is most effective in reducing 3.2.4. BP variability measured by ASBP and within-visit clinic BP |
| Secondary | Proportion of patients who achieve BP control | BP control measured in Clinic BP as measured at baseline, 2 month, 4 month and 6 month and ABP measured at baseline and 6 month | To determine which of the three single pill combinations of two antihypertensive agents is most effective in increasing the proportion of patients who achieve BP control defined as BP: \<140/90 mmHg and \<130/80mmHg at any of their clinic visits and maintained at the 6-month clinic visit. |
| Secondary | Proportion of patients classified as "responders" | Clinic BP as measured at baseline, 2 month, 4 month and 6 month | Proportion of patients classified as "responders" defined as those who had a reduction of SBP ≥20mmHg and DBP ≥10 mmHg at any of their clinic visits and maintained at the 6-month clinic visit. |
| Secondary | Micro- and macro-albuminuria | Change in serum albumin measured at baseline and 6 month | To determine the effect of three single pill combinations of two antihypertensive agents on Micro- and macro-albuminuria. |
| Secondary | Fasting blood glucose | Change in fasting blood glucose measured at baseline and 6 month | To determine the effect of three single pill combinations of two antihypertensive agents on Fasting blood glucose. |
| Secondary | Fasting lipid profile | Change in serum lipid profile measured at baseline and 6 month | To determine the effect of three single pill combinations of two antihypertensive agents on fasting lipid profile. |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 40715816 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05683301
GET https://conductscience.org/api/trials/v1/NCT05683301/registered