Trial · NCT05689554

Reducing CNS-Active Medications to Prevent Falls and Injuries in Older Adults

NCT05689554, Not applicable, Completed, University of Washington; results first posted 2024-12-09

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Reducing CNS-Active Medications to Prevent Falls and Injuries in Older Adults. Trials, record NCT05689554. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05689554

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Reducing CNS-Active Medications to Prevent Falls and Injuries in Older Adults
NCT number: NCT05689554
Status: Completed
Phases: Not applicable
Enrollment: 2,367 participants, actual
Lead sponsor: University of Washington
Conditions: Aging, Accidental Fall
Interventions: STOP Falls Educational Intervention
First posted: 2023-01-19
Last updated: 2024-12-09
Results first posted: 2024-12-09

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Medically Treated Falls	up to 26 months following intervention	Falls for which medical attention is sought
Secondary	Medication Discontinuation	6 months following intervention	Target medication has not been prescribed for 90 days 6 months post intervention

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Medically Treated Falls	up to 26 months following intervention		Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Medication Discontinuation	6 months following intervention	Number of participants who were not prescribed the target medication of interest 90 days post intervention	Participants	COUNT_OF_PARTICIPANTS

Source ClinicalTrials.gov

Results by group12

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Units
Medically Treated Falls	Intervention		328	Participants
Medically Treated Falls	Usual Care		349	Participants
Medication Discontinuation	Intervention	Opioids	32	Participants
Medication Discontinuation	Usual Care	Opioids	40	Participants
Medication Discontinuation	Intervention	Benzodiazepines	55	Participants
Medication Discontinuation	Usual Care	Benzodiazepines	49	Participants
Medication Discontinuation	Intervention	Tricyclic Antidepressants	34	Participants
Medication Discontinuation	Usual Care	Tricyclic Antidepressants	23	Participants
Medication Discontinuation	Intervention	Muscle Relaxants	34	Participants
Medication Discontinuation	Usual Care	Muscle Relaxants	40	Participants

1 to 10 of 12Source ClinicalTrials.gov

See all 12 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Units counted
Overall Study	STARTED	Intervention	1,106	9
Overall Study	STARTED	Usual Care	1,261	9
Overall Study	COMPLETED	Intervention	1,106	9
Overall Study	COMPLETED	Usual Care	1,261	9
Overall Study	NOT COMPLETED	Intervention	0	0
Overall Study	NOT COMPLETED	Usual Care	0	0

Source ClinicalTrials.gov

Adverse events2

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
serious	Serious adverse drug withdrawal events involving opioids or sedative-hypnotics	General disorders	Intervention	10	1,106	10
serious	Serious adverse drug withdrawal events involving opioids or sedative-hypnotics	General disorders	Usual Care	4	1,261	4

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Intervention	86	1,106
Total, all-cause mortality	Usual Care	72	1,261
Total, other adverse events	Intervention	0	1,106
Total, other adverse events	Usual Care	0	1,261
Total, serious adverse events	Intervention	10	1,106
Total, serious adverse events	Usual Care	4	1,261

Source ClinicalTrials.gov

Papers3

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
37170329	DERIVED	PubMed
39052289	DERIVED	PubMed
39360568	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons3

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Intervention vs Usual Care: Medically Treated Falls	Trial comparisons
Intervention vs Usual Care: deaths from any cause	Trial comparisons
Intervention vs Usual Care: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT05689554

GET https://conductscience.org/api/trials/v1/NCT05689554/registered

API reference For AI assistants