Trial · NCT05708274
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 13 of 13
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Assessing task performance (dexterity) | Assess change from baseline to 10 minutes after completion of drug+task training. | Unilateral manual dexterity will be assessed using the 9-Hole Peg Test (Aim 1a). |
| Secondary | Assessing task performance (dexterity) | Assess change from baseline to 10 minutes after completion of drug+task training. | Unilateral manual dexterity will be assessed using the Box and Block Test (Aim 1a). |
| Secondary | Assessing volitional grip strength | Assess change from baseline to 10 minutes after completion of drug+task training. | Maximal grip force will be measured (Aim 1b). The attempt with the highest value will be used for analysis. |
| Secondary | Assessing volitional pinch strength | Assess change from baseline to 10 minutes after completion of drug+task training. | Maximal pinch force will be measured (Aim 1b). The attempt with the highest value will be used for analysis. |
| Secondary | Assessing corticospinal plasticity | Assess change from baseline to 10 minutes after completion of drug+task training. | Corticospinal plasticity will be measured via single-pulse TMS recruitment curves (Aim 2a). |
| Secondary | Assessing cortical plasticity | Assess change from baseline to 10 minutes after completion of drug+task training. | Short intracortical inhibition (SICI) and intracortical facilitation (ICF) will be evoked with paired-pulse TMS at various interstimulus intervals according to the methods previously employed (Murray \& Knikou, 2017). |
| Secondary | Assessing spinal plasticity | Assess change from baseline to 10 minutes after completion of drug+task training. | Spinal plasticity will be measured via single-pulse TSCS recruitment curves (Aim 2b). |
| Secondary | Tracking cardiovascular responses (heart rate) | Measured every 5-10 minutes, for up to 4 hours. Change will be compared to baseline. | Observed measures of heart rate (HR) (Aim 3a) will be monitored throughout. |
| Secondary | Tracking cardiovascular responses (blood oxygen saturation) | Measured every 5-10 minutes, for up to 4 hours. Change will be compared to baseline. | Observed measures of blood oxygen saturation (SpO2) (Aim 3a) will be monitored throughout. |
| Secondary | Tracking cardiovascular responses (blood pressure) | Measured every 5-10 minutes, for up to 4 hours. Change will be compared to baseline. | Observed measures of blood pressure (BP) (Aim 3a) will be monitored throughout. |
| Secondary | Tracking symptoms | Measured every 5-10 minutes, for up to 4 hours. Change will be compared to baseline. | Participant-reported safety questionnaire (Aim 3b) will be monitored for any symptoms felt throughout the study. |
| Secondary | Tracking side effects (drug administration) | Assess change from end of day 1 testing to 24 hours after study completion. | Adverse event (AE) questionnaire (Aim 3b) related to any participant-reported experience following drug administration. |
| Secondary | Tracking side effects (study testing stimulation) | Assess change from end of day 1 testing to 24 hours after study completion. | Adverse event (AE) questionnaire (Aim 3b) related to any participant-reported experience following brain and/or spinal stimulation received during the experiment. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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