Weight Discrimination and Poor Cardiovascular Health

NCT05714696, Not applicable, Completed, Florida State University; results first posted 2025-05-15

Trial 12

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Field	Value	Source
Title	Weight Discrimination and Poor Cardiovascular Health	ClinicalTrials.gov
NCT number	NCT05714696	ClinicalTrials.gov
Status	Completed	ClinicalTrials.gov
Phases	Not applicable	ClinicalTrials.gov
Enrollment	333 participants, actual	ClinicalTrials.gov
Lead sponsor	Florida State University	ClinicalTrials.gov
Conditions	Obesity	ClinicalTrials.gov
Interventions	Weight discrimination experience, Control experience	ClinicalTrials.gov
First posted	2023-02-06	ClinicalTrials.gov
Last updated	2025-05-15	ClinicalTrials.gov
Results first posted	2025-05-15	ClinicalTrials.gov
Limitations and caveats	Because the of mechanism used to fund this project (R56), we received only one year of funding and thus we were not able to reach our desired sample size of 320 participants.	ClinicalTrials.gov

Registered outcomes 11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description	Source
Primary	Negative Affect	2 minutes after delivery of the intervention	A modified version of the Positive and Negative Affect Scale-Expanded Form (PANAS-X) will be used to assess emotions in response to the experimental manipulation. The scale demonstrates good validity and reliability. Emotions will be assessed with 46 adjectives (e.g., angry, confident) by indicating the extent to each emotion is felt at that moment (1=very slightly or not at all to 5=extremely). A composite score for negative affect will be created by taking the average of the relevant adjectives. Scores will range from 1 to 5, with higher scores indicating more negative emotion.	ClinicalTrials.gov
Primary	Positive Affect	2 minutes after delivery of the intervention	A modified version of the Positive and Negative Affect Scale-Expanded Form (PANAS-X) will be used to assess emotions in response to the experimental manipulation. The scale demonstrates good validity and reliability. Emotions will be assessed with 46 adjectives (e.g., angry, confident) by indicating the extent to each emotion is felt at that moment (1=very slightly or not at all to 5=extremely). A composite score for positive affect will be created by taking the average of the relevant adjectives. Scores will range from 1 to 5, with higher scores indicating more positive emotion.	ClinicalTrials.gov
Primary	Self-efficacy for Weight Control Behavior	6 minutes after delivery of the intervention	Self-efficacy (perceived confidence) in one's ability to engage in weight control behaviors (e.g., dietary restraint, physical activity) over the next six months will be assessed. Self-efficacy for dietary restraint will be assessed with the short form of the Weight Efficacy Lifestyle Questionnaire (e.g., I can resist eating … when I am depressed or down; 8 items). Self-efficacy for physical activity will be assessed with the Exercise Self-efficacy Scale (e.g., I am confident I can participate in regular exercise when … I am tired; 5 items). Weight control items will be interspersed with items assessing self-efficacy for other health behaviors (e.g., flu vaccination, sleep). Each item will be rated on an 8-point scale (0=not at all confident to 7=very confident). Items will be averaged to create a composite score. Scores will range from 0 to 7, with higher scores indicating higher self-efficacy for weight control behavior.	ClinicalTrials.gov
Primary	Intentions for Weight Control Behavior	10 minutes after delivery of the intervention	Using the same health behaviors assessed for self-efficacy, intentions for weight control behavior will be assessed (i.e., intentions to engage in each behavior over the next six months). Each item will be rated on an 8-point scale (0=strongly disagree to 7=strongly agree). Items will be averaged to create a composite score. Scores will range from 0 to 7, with higher scores indicating higher intentions to engage in weight control behavior.	ClinicalTrials.gov
Primary	Executive control_accuracy	15 minutes after delivery of the intervention	The Stroop task provides a measure of executive control by assessing the ability to inhibit an automatic response (reading) in favor of performing a more controlled task (color naming). The task is a classic, widely used and well-validated measure of executive control. Eight blocks of 20 trials will be performed that will take approximately 5 minutes to complete. Executive control scores will be calculated for response accuracy and speed. Metric: accuracy (percentage of correct answers on mismatched trials). A lower percentage of correct answers on mismatched trials indicates worse executive control.	ClinicalTrials.gov
Primary	Executive control_speed	15 minutes after delivery of the intervention	The Stroop task provides a measure of executive control by assessing the ability to inhibit an automatic response (reading) in favor of performing a more controlled task (color naming). The task is a classic, widely used and well-validated measure of executive control. Eight blocks of 20 trials will be performed that will take approximately 5 minutes to complete. Executive control scores will be calculated for accuracy and speed (reaction time). Metric: reaction time (average reaction time in milliseconds on mismatched trials). Longer reaction times on mismatched trials indicate worse executive control.	ClinicalTrials.gov
Primary	Delay Discounting	20 minutes after delivery of the intervention	Delay discounting involves the subjective depreciation of an incentive based on its timing. The measure assesses the ability to delay gratification, that is, a tendency to prioritize larger long-term rewards over smaller short-term rewards. The task involves choosing short vs. long-term rewards from a set of five dichotomous choices (e.g., to receive $1 immediately or $10 in one month). The task takes about 1 minute to administer, is highly reliable, and correlates well with longer and more extensive measures of delay discounting (metric: discount rate (k)). Scores will range from 0.000110 to 24, with higher scores indicating more impulsivity/lower ability to delay gratification.	ClinicalTrials.gov
Primary	Change in Cortisol From Baseline to First Follow-up Assessment	25 minutes after delivery of the intervention	The investigators will measure cortisol secretion via saliva (passive drool) 25 minutes after delivery of the intervention (first follow-up) and compare it to baseline cortisol levels.	ClinicalTrials.gov
Primary	Comfort Eating	30 minutes after delivery of the intervention	Comfort eating will be assessed via an eating task to objectively measure hyper-palatable (high-fat, -sodium, -sugar, and -carbohydrate) food intake. To avoid floor effects, the eating task will take place under the guise of a faux taste test, which will ostensibly guide the development of the food marketing campaign later during the study. To avoid ceiling effects and to allow eating behavior without fear that the experimenter will negatively judge the amount eaten, large quantities of each food will be made available. The task will take 10 minutes to complete and will be conducted in a private room. Bowls will be weighed (unobtrusively) before and after the task to compute the difference in grams, which will then be converted to kilocalories based on published nutrition information from the food maker. Higher kilocalorie consumption indicates a tendency to engage in more comfort eating during times of stress.	ClinicalTrials.gov
Primary	Social Withdrawal	45 minutes after delivery of the intervention	Social withdrawal will be assessed with a measure from previous research. The experimenter will present three options for working on the final task: alone, with a former group member, or with a new partner. Choosing to work alone reflects a desire to avoid social interaction. Each response will be assigned a numerical code (work alone = 0; work with a former group member = 1; work with a new partner = 2). Scores of zero indicate a greater tendency to withdraw socially during times of stress.	ClinicalTrials.gov
Primary	Change in Cortisol From Baseline to Second Follow-up Assessment	60 minutes after delivery of the intervention	The investigators will measure cortisol secretion via saliva (passive drool) 60 minutes after delivery of the intervention (second follow-up) and compare it to baseline cortisol levels.	ClinicalTrials.gov

Outcomes 11

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as	Source
PRIMARY	Negative Affect	2 minutes after delivery of the intervention		score on a scale	MEAN	ClinicalTrials.gov
PRIMARY	Positive Affect	2 minutes after delivery of the intervention		score on a scale	MEAN	ClinicalTrials.gov
PRIMARY	Self-efficacy for Weight Control Behavior	6 minutes after delivery of the intervention		score on a scale	MEAN	ClinicalTrials.gov
PRIMARY	Intentions for Weight Control Behavior	10 minutes after delivery of the intervention		score on a scale	MEAN	ClinicalTrials.gov
PRIMARY	Executive control_accuracy	15 minutes after delivery of the intervention	There are some missing data on this variable due to experimenter error.	percentage of correct responses	MEAN	ClinicalTrials.gov
PRIMARY	Executive control_speed	15 minutes after delivery of the intervention	There are some missing data on this variable due to experimenter error.	milliseconds	MEAN	ClinicalTrials.gov
PRIMARY	Delay Discounting	20 minutes after delivery of the intervention	There are some missing data on this variable due to experimenter error.	score on a scale	MEAN	ClinicalTrials.gov
PRIMARY	Change in Cortisol From Baseline to First Follow-up Assessment	25 minutes after delivery of the intervention	There are some missing data on this variable due to poor quality saliva samples (too watery).	ug/dL	MEAN	ClinicalTrials.gov
PRIMARY	Comfort Eating	30 minutes after delivery of the intervention	There are some missing data on this variable due to participant eating restrictions or allergies that prevented them completing the taste test as designed.	kcals	MEAN	ClinicalTrials.gov
PRIMARY	Social Withdrawal	45 minutes after delivery of the intervention	One participant is missing data due to experimenter error.	Participants	COUNT_OF_PARTICIPANTS	ClinicalTrials.gov
PRIMARY	Change in Cortisol From Baseline to Second Follow-up Assessment	60 minutes after delivery of the intervention	There are some missing data on this variable due to poor quality saliva samples (too watery). Of note, we were not able to run the statistical analysis on this variable due to the lack of variability in both groups.	ug/dL	MEAN	ClinicalTrials.gov

Results by group 26

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units	Source
Negative Affect	Weight Discrimination Experience		1.43	Standard Deviation 0.49	score on a scale	ClinicalTrials.gov
Negative Affect	Control Experience		1.29	Standard Deviation 0.33	score on a scale	ClinicalTrials.gov
Positive Affect	Weight Discrimination Experience		2.83	Standard Deviation 0.94	score on a scale	ClinicalTrials.gov
Positive Affect	Control Experience		3.04	Standard Deviation 0.82	score on a scale	ClinicalTrials.gov
Self-efficacy for Weight Control Behavior	Weight Discrimination Experience		4.29	Standard Deviation 1.42	score on a scale	ClinicalTrials.gov
Self-efficacy for Weight Control Behavior	Control Experience		3.91	Standard Deviation 1.42	score on a scale	ClinicalTrials.gov
Intentions for Weight Control Behavior	Weight Discrimination Experience		4.91	Standard Deviation 1.30	score on a scale	ClinicalTrials.gov
Intentions for Weight Control Behavior	Control Experience		4.70	Standard Deviation 1.28	score on a scale	ClinicalTrials.gov
Executive control_accuracy	Weight Discrimination Experience		96	Standard Deviation 5.0	percentage of correct responses	ClinicalTrials.gov
Executive control_accuracy	Control Experience		96	Standard Deviation 4.7	percentage of correct responses	ClinicalTrials.gov
Executive control_speed	Weight Discrimination Experience		1191	Standard Deviation 429	milliseconds	ClinicalTrials.gov
Executive control_speed	Control Experience		1362	Standard Deviation 492	milliseconds	ClinicalTrials.gov
Delay Discounting	Weight Discrimination Experience		0.86	Standard Deviation 3.87	score on a scale	ClinicalTrials.gov
Delay Discounting	Control Experience		1.20	Standard Deviation 4.78	score on a scale	ClinicalTrials.gov
Change in Cortisol From Baseline to First Follow-up Assessment	Weight Discrimination Experience		.0000	Standard Deviation .0000	ug/dL	ClinicalTrials.gov
Change in Cortisol From Baseline to First Follow-up Assessment	Control Experience		.0076	Standard Deviation .0874	ug/dL	ClinicalTrials.gov
Comfort Eating	Weight Discrimination Experience		299.42	Standard Deviation 194.72	kcals	ClinicalTrials.gov
Comfort Eating	Control Experience		365.73	Standard Deviation 173.83	kcals	ClinicalTrials.gov
Social Withdrawal	Weight Discrimination Experience	Work by self	72		Participants	ClinicalTrials.gov
Social Withdrawal	Control Experience	Work by self	55		Participants	ClinicalTrials.gov

Participant flow 6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Source
Overall Study	STARTED	Weight Discrimination Experience	136	ClinicalTrials.gov
Overall Study	STARTED	Control Experience	135	ClinicalTrials.gov
Overall Study	COMPLETED	Weight Discrimination Experience	136	ClinicalTrials.gov
Overall Study	COMPLETED	Control Experience	135	ClinicalTrials.gov
Overall Study	NOT COMPLETED	Weight Discrimination Experience	0	ClinicalTrials.gov
Overall Study	NOT COMPLETED	Control Experience	0	ClinicalTrials.gov

Adverse events 0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events	Source

Adverse event totals 6

The totals the trial posted for each group.

Total	Group	At risk	Source
Total, all-cause mortality	Weight Discrimination Experience	136	ClinicalTrials.gov
Total, all-cause mortality	Control Experience	135	ClinicalTrials.gov
Total, other adverse events	Weight Discrimination Experience	136	ClinicalTrials.gov
Total, other adverse events	Control Experience	135	ClinicalTrials.gov
Total, serious adverse events	Weight Discrimination Experience	136	ClinicalTrials.gov
Total, serious adverse events	Control Experience	135	ClinicalTrials.gov

Papers 0

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source

Trial comparisons 2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Weight Discrimination Experience vs Control Experience: deaths from any cause	Trial comparisons
Weight Discrimination Experience vs Control Experience: serious adverse events	Trial comparisons

Tests 2

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

Test	Named as	Source
Delay Discounting	Primary outcome	ConductCognition
Stroop Color-Word Test	Primary outcome	ConductCognition

Source 4

Field	Value	Source
Release	trials-2026-11-12-0.3.0	ClinicalTrials.gov
Release manifest SHA-256	4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391	ClinicalTrials.gov
Registry capture	2026-11-12	ClinicalTrials.gov
Results copy, AACT	2026-03-23	ClinicalTrials.gov

The same record as JSON

Release trials-2026-11-12-0.3.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.