CERebrolysin In CADASIL
NCT05755997, Phase 2, Active not recruiting, Ever Neuro Pharma GmbH
Trial 11
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | CERebrolysin In CADASIL | ClinicalTrials.gov |
| NCT number | NCT05755997 | ClinicalTrials.gov |
| Status | Active not recruiting | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 30 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Ever Neuro Pharma GmbH | ClinicalTrials.gov |
| Conditions | Cadasil | ClinicalTrials.gov |
| Interventions | Cerebrolysin, 0.9 % NaCl | ClinicalTrials.gov |
| First posted | 2023-03-06 | ClinicalTrials.gov |
| Last updated | 2025-02-25 | ClinicalTrials.gov |
| Other registries' IDs | eudract:2022-002394-29 | ClinicalTrials.gov |
Registered outcomes 49
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in cognitive battery (RAVLT) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Rey Auditory Verbal Learning Test (AVLT) | ClinicalTrials.gov |
| Primary | Change in cognitive battery (ROCF: Copy, immediate recall) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Rey-Osterrieth Complex Figure Test (ROCF): Copy, immediate recall | ClinicalTrials.gov |
| Primary | Change in cognitive battery (Digit Symbol Coding, subscale of WAIS-PSI) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Digit Symbol Coding (subscale of WAIS-PSI) | ClinicalTrials.gov |
| Primary | Change in cognitive battery (Digit Span: Digit backward (subscale of WAIS-WMI) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Digit Span: Digit backward (subscale of WAIS-WMI) | ClinicalTrials.gov |
| Primary | Change in cognitive battery (Trail Making Test, Part B) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Trail Making Test (Part B) | ClinicalTrials.gov |
| Primary | Change in cognitive battery (ROCF: Delayed recall) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Rey-Osterrieth Complex Figure Test (ROCF): Delayed recall | ClinicalTrials.gov |
| Primary | Change in cognitive battery (Stroop Color and Word Test - Prague Version) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Stroop Color and Word Test - Prague Version (word/dots interference) | ClinicalTrials.gov |
| Primary | Change in cognitive battery (MoCA) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Montreal Cognitive Assessment (MoCA) | ClinicalTrials.gov |
| Primary | Change in mood (Beck Depression Inventory-II) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Beck Depression Inventory-II (BDI-II) | ClinicalTrials.gov |
| Primary | Change in imaging (White matter lesion volume) | Baseline, Month 12, Month 27 | \- White matter lesion volume (MRI) | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Spatial Pattern Separation Task) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Spatial Pattern Separation Task | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Navigation Test Suite) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Navigation Test Suite | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Trail Making Test, Part A) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Trail Making Test (Part A) | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Stroop Color and Word Test - Prague Version) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Stroop Color and Word Test - Prague Version (color-word/dots interference) | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Symbol Search, subscale of WAIS-PSI) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Symbol Search (subscale of WAIS-PSI) | ClinicalTrials.gov |
| Secondary | Change in cognitive battery, secondary outcome (Digit Span: Digit forward, subscale of WAIS-WMI) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Digit Span: Digit forward (subscale of WAIS-WMI) | ClinicalTrials.gov |
| Secondary | Change in mood, secondary outcome (Beck Anxiety Inventory) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- Beck Anxiety Inventory | ClinicalTrials.gov |
| Secondary | Change in neurological deficits, secondary outcome (NIH stroke scale) | Baseline, Month 6, Month 12, Month 21, Month 27 | \- NIH stroke scale (NIHSS) | ClinicalTrials.gov |
| Secondary | Change in imaging, secondary outcome (Index of general cortical thinning) | Baseline, Month 12, Month 27 | \- Index of general cortical thinning (MRI) | ClinicalTrials.gov |
| Secondary | Change in imaging, secondary outcome (Post-stroke lacune volume) | Baseline, Month 12, Month 27 | \- Post-stroke lacune volume (MRI) | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 9
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Complex Figure Copy and Recall | Primary outcome | ConductCognition |
| Digit Span Test | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Verbal Learning | Primary outcome | ConductCognition |
| Mnemonic Similarity Task | Secondary outcome | ConductCognition |
| Symbol Scan Task | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)