Trial · NCT05767229
Acute Hemodynamic Response to Carvedilol in Children With Clinically Significant Portal Hypertension.
NCT05767229, Not applicable, Completed, Institute of Liver and Biliary Sciences, India
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Acute Hemodynamic Response to Carvedilol in Children With Clinically Significant Portal Hypertension. Trials, record NCT05767229. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05767229
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Acute Hemodynamic Response to Carvedilol in Children With Clinically Significant Portal Hypertension.
- NCT number
- NCT05767229
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 40 participants, actual
- Lead sponsor
- Institute of Liver and Biliary Sciences, India
- Conditions
- Portal Hypertension
- Interventions
- Carvedilol
- First posted
- 2023-03-14
- Last updated
- 2025-01-08
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of children with acute hemodynamic response 90 mins after carvedilol given through nasogastric route) in those with clinically significant portal hypertension. | 90 minutes | Acute hemodynamic response (HVPG reduction to less than 12 mm Hg or by more than equals to 20% from initial value |
| Secondary | HVPG values in children (2-18 years age) with different etiologies of chronic liver disease. | Day 0 | |
| Secondary | Proportion of children with presence of varices and clinically significant varices in children with HVPG more than equal to 10 in different etiologies of liver disease.. | Day 0 | |
| Secondary | Proportion of children with presence of varices and clinically significant varices in children with HVPG less than 10 mm Hg in different etiologies of liver disease. | Day 0 | |
| Secondary | Splenic Z-scores, Liver and splenic stiffness in children with HVPG more than equal to 10 or less than 10 mm Hg in different etiologies of liver disease. | Day 0 | |
| Secondary | Bile acid levels in children with HVPG more than equal to 10 or less than 10 mm Hg in different etiologies of liver disease. | Day 0 | |
| Secondary | Risk factors of acute hemodynamic response on univariate and multivariate binary logistic regression analysis. | Day 0 | |
| Secondary | Change in the grading (low or high risk) of esophageal varices at 6 months after starting oral carvedilol in children with or without acute hemodynamic response. | 6 months |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05767229
GET https://conductscience.org/api/trials/v1/NCT05767229/registered