Trial · NCT05771584
Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer
NCT05771584, Phase 2, Active not recruiting, Aston Sci. Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer. Trials, record NCT05771584. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05771584
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer
- NCT number
- NCT05771584
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 24 participants, actual
- Lead sponsor
- Aston Sci. Inc.
- Conditions
- Gastric Cancer
- Interventions
- AST-301, rhuGM-CSF
- First posted
- 2023-03-16
- Last updated
- 2026-07-22
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of participants with treatment-related adverse events as assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE] version 5.0. | up to 20 weeks | To assess the safety of AST-301 administered in gastric cancer patients. |
| Primary | Immunologic efficacy of AST-301 immunization | 52 weeks | AST-301 specific interferon (IFN)-gamma enzyme-linked immune absorbent spot (ELISpot) assay |
| Secondary | 1year Disease-Free Survival rate (DFS rate) | 12 months | disease free survival rate at 1 year |
| Secondary | Disease-Free Survival rate (DFS rate) at end of study (EOS) | Overall study period approximately 31 months | disease free survival at end of study |
| Secondary | Compare immunogenicity of AST-301 between Arm 1 and Arm 2 | 52 weeks | AST-301-specific IFN γ response by ELISpot assay |
| Secondary | Change in central memory T-cell populations between Arm 1 and Arm 2 | 52 weeks | Central memory T-cell (cluster of differentiation 4 (CD4) + and cluster of differentiation 8 (CD8) +) by a flow cytometry analysis |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05771584
GET https://conductscience.org/api/trials/v1/NCT05771584/registered