Registered outcomes19

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 19 of 19

List	Outcome	Time frame	Description
Primary	Luteinizing hormone in serum	before and after 2, 12 weeks of intervention	Changes of luteinizing hormone(mIU/mL) in serum after the intervention.
Primary	4-Androstenedione in serum	before and after 2, 12 weeks of intervention	Changes of 4-Androstenedione(pmol/L) in serum after the intervention.
Secondary	Testosterone in serum	before and after 2, 12 weeks of intervention	Changes of testosterone(nmol/L) in serum after the intervention.
Secondary	Estradiol in serum	before and after 2, 12 weeks of intervention	Changes of estradiol(pmol/L) in serum after the intervention.
Secondary	Prolactin in serum	before and after 2, 12 weeks of intervention	Changes of prolactin(ng/mL) in serum after the intervention.
Secondary	Follicle number	after 12 weeks of intervention	The number of all antral follicles in each ovary will be determined using transvaginal ultrasonography for each participant.
Secondary	Follicle number	before intervention	The number of all antral follicles in each ovary will be determined using transvaginal ultrasonography for each participant.
Secondary	Ovarian volume	after 12 weeks of intervention	The size of each ovary will be determined using transvaginal ultrasonography for each participant in early follicular phase.
Secondary	Ovarian volume	before intervention	The size of each ovary will be determined using transvaginal ultrasonography for each participant in early follicular phase.
Secondary	The alterations of plasma lipid metabolites	after 12 weeks of intervention	Determination the alterations of lipid metabolites before and after metformin intervention by metabolomics.
Secondary	The alterations of plasma lipid metabolites	after 2 weeks of intervention	Determination the alterations of lipid metabolites before and after metformin intervention by metabolomics.
Secondary	The alterations of plasma lipid metabolites	before intervention	Determination the alterations of lipid metabolites before and after metformin intervention by metabolomics.
Secondary	Fasting insulin	before and after 2, 12 weeks of intervention	Changes in plasma insulin concentration after the intervention.
Secondary	Blood sugar level	before and after 2, 12 weeks of intervention	Changes in plasma glucose concentration after the intervention.
Secondary	The alterations of secondary metabolites of gut fungi and bacteria	after 12 weeks of intervention	Determination the alterations of secondary metabolites of gut fungi and bacteria before and after metformin intervention by metabolomics
Secondary	The alterations of secondary metabolites of gut fungi and bacteria	after 2 weeks of intervention	Determination the alterations of secondary metabolites of gut fungi and bacteria before and after metformin intervention by metabolomics
Secondary	The alterations of secondary metabolites of gut fungi and bacteria	before intervention	Determination the alterations of secondary metabolites of gut fungi and bacteria before and after metformin intervention by metabolomics
Secondary	The species and genus abundance changes of fungi and bacteria gut microbiota composition	before and after 2, 12 weeks of intervention	Determination the species and genus abundance changes of gut microbiota among before and after intervention by ITS genomic
Secondary	Follicular stimulating hormone in serum	before and after 2, 12 weeks of intervention	Changes of follicular stimulating hormone(mIU/mL) in serum after the intervention.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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