Trial · NCT05814640
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
NCT05814640, Phase 1, Phase 2, Recruiting, First Affiliated Hospital of Chongqing Medical University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD). Trials, record NCT05814640. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05814640
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
- NCT number
- NCT05814640
- Status
- Recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 520 participants, estimated
- Lead sponsor
- First Affiliated Hospital of Chongqing Medical University
- Conditions
- Depression, Sequestra
- Interventions
- Fluoxetine, Sertraline, Vortioxetine, Duloxetine, Aripiprazole, Lithium Carbonate, Olanzapine, GCBT
- First posted
- 2023-04-18
- Last updated
- 2026-01-27
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in CDRS-R (Children's Depression Rating Scale) scores from baseline | Baseline of treatment period, 2 weeks, 1 month, 2 months, 3 months，4months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Clinical response (≥ 50% reduction in CDRS-R scores from baseline) |
| Secondary | Change in BDI-II (Baker Depression Scale) scores from baseline | Baseline of treatment period, 1 month, 2 months, 3 months，4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Change in BDI-II (Baker Depression Scale) scores from baseline |
| Secondary | Change in SCARED (The Screen for Child Anxiety-Related Emotional Disorders) scores from baseline | Baseline of treatment period, 1 month, 2 months, 3 months，4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Improvement in anxiety (SCARED minus the scores） |
| Secondary | Change in suicide risk from baseline on the C-SSRS (Columbia Suicide Severity Rating Scale) | Baseline of treatment period, 1 month, 2 months, 3 months，4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | The severity of the suicide risk |
| Secondary | Change in PSQI (Pittsburgh Sleep Quality Index) scores from baseline | Baseline of treatment period, 2 month, 4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Improvement in sleep status (PSQI minus the scores） |
| Secondary | Change in PedsQL4.0 (The Pediatric Quality of Life Inventory) scores from baseline | Baseline of treatment period, 2 month, 4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Improvement of children's quality of life（PedsQL4.0 minus the scores) |
| Secondary | Change in CGI-S (Clinical Global Impressions-Severity Scales) scores from baseline | Baseline of treatment period, 1 month, 2 months, 3 months，4 months. | Improvement in overall clinical impression severity（ 7-point scale, with 1 being normal and 7 being among the most severely damaged） |
| Secondary | Change in CGI-I (Clinical Global Impressions-Improvement Scales) scores from baseline | The treatment period was 1 month, 2 months, 3 months，4 months. | Improvement of clinical general Impression scale（ 7-point scale,7 denoting a very significant deterioration） |
| Secondary | Change in RSS (Ruminative Responses Scale) | The treatment period was 1 month, 2 months. | The level of improvement in negative thinking（he higher the total score, the more reflective thinking The more severe it is） |
| Secondary | Change in HCL-32（Hypomania Symptom Checklist-32） | Baseline of treatment period, 1 month, 2 months, 3 months，4 months; The follow-up period was 1 month, 3 months, 6 months and 12 months | Assess the patient's hypomanic state |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers60
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05814640
GET https://conductscience.org/api/trials/v1/NCT05814640/papers?page=2