Trial · NCT05827055
Proglumide and Chemotherapy for Metastatic Pancreatic Cancer
NCT05827055, Phase 2, Active not recruiting, Georgetown University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Proglumide and Chemotherapy for Metastatic Pancreatic Cancer. Trials, record NCT05827055. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05827055
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Proglumide and Chemotherapy for Metastatic Pancreatic Cancer
- NCT number
- NCT05827055
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Georgetown University
- Conditions
- Metastatic Pancreatic Cancer
- Interventions
- Gemcitabine, Nab paclitaxel, Proglumide, Placebo
- First posted
- 2023-04-24
- Last updated
- 2026-06-10
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Safety of oral proglumide therapy at 1200mg daily dose with chemotherapy | 18 months | The number of abnormal serum chemistry values occurring in those on proglumide compared to those on placebo |
| Secondary | Fibrosis in the pancreatic tumor microenvironment | 3 years | The amount of fibrosis measured on the tumor biopsy with histologic staining in subjects on the proglumide arm compared to the measurment of fibrosis (by intergartive density score) to those on placebo |
| Secondary | Overall survival (OS) | 4 years | median overall survival will be estimated using Kaplan-Meier curves. |
| Secondary | Progression-free survival | 4 years | median progression free survival will be estimated using Kaplan-Meier curves. |
| Secondary | Effects of proglumide on Pain | 4 years | compare pain intensity and management in those on proglumide compared to placebo using the McGill Pain Survey. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05827055
GET https://conductscience.org/api/trials/v1/NCT05827055/registered