Trial · NCT05858216
First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study
NCT05858216, Early phase 1, Completed, Auburn University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study. Trials, record NCT05858216. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05858216
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study
- NCT number
- NCT05858216
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 8 participants, actual
- Lead sponsor
- Auburn University
- Conditions
- Voice Disorder Due to Iatrogenic Factor
- Interventions
- Chlor-Trimeton.
- First posted
- 2023-05-15
- Last updated
- 2024-04-24
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Urine specific gravity (g/ml) | Start of trial | Objective measurement of systemic hydration |
| Primary | Fundamental frequency (Hertz) | Change from Baseline Fundamental Frequency at 3 hours | Sustained "a" task from which the cycles of vocal fold vibration per second are extracted. |
| Primary | Speaking fundamental frequency (Hertz) | Change from Baseline Fundamental Frequency at 3 hours | Standard reading task from which the average cycles per second of vocal fold vibration are extracted. |
| Primary | Harmonic-to-Noise ratio (decibels, dB) | Change from Baseline Fundamental Frequency at 3 hours | Sustained "a" task from which a ratio of the harmonic acoustic components of the signal relative to the noise components of the acoustic signal are determined |
| Primary | Cepstral peak prominence (decibels, dB) | Change from Baseline Fundamental Frequency at 3 hours | An acoustic measurement of voice quality deviation that is extracted from a recorded speech sample. |
| Primary | Phonation threshold pressure (cm/H20) | Change from Baseline Fundamental Frequency at 3 hours | An aerodynamic measurement of the minimum amount of subglottal pressure required to initiate vocal fold vibration for voicing |
| Primary | Videostroboscopy (video of vocal fold vibration) | Change from Baseline Fundamental Frequency at 3 hours | Standard clinical endoscopic imaging of laryngeal structure and function |
| Primary | OMNI-Vocal Effort Scale (scaled score) | Change from Baseline Fundamental Frequency at 3 hours | A validated scale of perceived vocal effort that provides a scale of 1-10 from which to determine how much vocal effort was produced. |
| Primary | Rating-of-Fatigue (ROF; scaled score) | Change from Baseline Fundamental Frequency at 3 hours | A validated scale of perceived voice fatigue |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05858216
GET https://conductscience.org/api/trials/v1/NCT05858216/registered