Trial · NCT05903417
Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic
NCT05903417, Not applicable, Completed, National University of Malaysia
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic. Trials, record NCT05903417. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05903417
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic
- NCT number
- NCT05903417
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 40 participants, actual
- Lead sponsor
- National University of Malaysia
- Conditions
- Pleural Infection
- Interventions
- Intrapleural fibrinolytic with alteplase 5mg and pulmozyme 5 mg, Saline irrigation with 250 mls normal saline (over 1 hour)
- First posted
- 2023-06-15
- Last updated
- 2026-02-24
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | to compare of the safety outcome between IPFT and intrapleural saline irrigation. | Day 7 | Number of participants who developed clinical deterioration, chest pain requiring escalation of analgesics, gastrointestinal bleeding, bleeding from chest drain site, intrapleural hemorrhage, hemoptysis, Hemoglobin (Hb) drop \>10% from baseline requiring blood transfusion |
| Secondary | To measure the change in the area of pleural opacity in chest x-ray compared to baseline | Day 7 | measured as the percentage of the ipsilateral hemithorax occupied by effusion. The area of pleural opacity and the area of the ipsilateral hemithorax will be measured digitally by two radiologists using Horos Project Software, v3.2.1 as described previously in Multicentre Intrapleural Sepsis Trial 2 (MIST-2) |
| Secondary | Changes in Inflammatory markers including serum C-reactive protein (CRP) & white blood count | Day 7 | reduction of inflammatory markers trend |
| Secondary | Length of hospitalization | through admission (up to 30 days) | measured in days |
| Secondary | the need for surgical referral | throughout admission up to 30 days | If failed intrapleural fibrinolytic or pleural irrigation (Discretion of treating physician) |
| Secondary | to evaluate the volume of pleural effusion drainage (in mls) 72 hours following randomization. | 72 hours | The net volume of pleural effusion drained measured after subtracting the |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41566445 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05903417
GET https://conductscience.org/api/trials/v1/NCT05903417/registered