Trial · NCT05992571
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
NCT05992571, Not applicable, Unknown, McMaster University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity. Trials, record NCT05992571. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05992571
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
- NCT number
- NCT05992571
- Status
- Unknown
- Phases
- Not applicable
- Enrollment
- 30 participants, estimated
- Lead sponsor
- McMaster University
- Conditions
- Cerebrovascular Function, Cognition
- Interventions
- Placebo, β-OHB
- First posted
- 2023-08-15
- Last updated
- 2023-12-01
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Brain network connectivity | 90 minutes | Functional connectivity of the default mode network (DMN) is measured via functional MRI. Changes in BOLD signal in each region are determined by independent component analysis and then functional connectivity is measured as a Pearson correlation (r) between the neural regions comprising the DMN and transformed into a z score. |
| Primary | Cerebral blood flow | 90 minutes | Sum of blood flow in the internal carotid and vertebral arteries via phase contrast MRI in ml/min. |
| Secondary | Working memory | 90 minutes | Computer battery to assess working memory (n-back test) based on N2 reaction time |
| Secondary | Executive function | 90 minutes | Computer battery to assess executive function (Stroop test) based on Stroop Cost (reaction times to incongruent stimuli minus congruent stimuli). |
| Secondary | Attention and working memory | 90 minutes | Computer battery to assess working memory (digit symbol substitution task) based on the number of correct responses in 120 seconds. |
| Other | Mean arterial pressure | 90 minutes | Automated blood pressure cuff measurement of brachial artery pressure in mmHg. |
| Other | Plasma beta-hydroxybutyrate | 90 minutes | Measured via finger capillary samples in mM |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Secondary outcome | ConductCognition |
| 2-Back Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05992571
GET https://conductscience.org/api/trials/v1/NCT05992571/registered