Trial · NCT06020456
Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A
NCT06020456, Completed, Groupe Maladies hémorragiques de Bretagne
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A. Trials, record NCT06020456. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06020456
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A
- NCT number
- NCT06020456
- Status
- Completed
- Enrollment
- 361 participants, actual
- Lead sponsor
- Groupe Maladies hémorragiques de Bretagne
- Conditions
- Carrier of Hemophilia A, Desmopressin, Factor VIII Deficiency
- Interventions
- Desmopressin
- First posted
- 2023-08-31
- Last updated
- 2023-08-31
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Comparison of the post-DDAVP FVIII peak in patients of the group "Null variants" vs "No Null variants" | FVIII levels 30-60 minutes after the DDAVP infusion | Factor VIII levels measured with a chronometric one stage-assay 30 or 60 minutes after the DDAVP infusion |
| Primary | Comparison of the post-DDAVP FVIII recovery in patients of the group "Null variants" vs "No Null variants" | FVIII levels before and 30-60 minutes after the DDAVP infusion | Factor VIII levels measured with a chronometric one stage-assay before (basal FVIII) the DDAVP infusion and 30 or 60 minutes after (FVIII peak). The FVIII recovery = ratio FVIII peak / basal FVIII |
| Primary | Comparison of the post-DDAVP FVIII clearance in patients of the group "Null variants" vs "No Null variants" | Factor VIII levels were measured until 24 hours after the desmopressin infusion | Factor VIII levels measured with a chronometric one stage-assay before and after DDAVP until 24h post-infusion |
| Primary | Comparison of the post-DDAVP FVIII area under the curve (AUC) in patients of the group "Null variants" vs "No Null variants" | Factor VIII levels were measured until 24 hours after the desmopressin infusion | Factor VIII levels measured with a chronometric one stage-assay before and after DDAVP until 24h post-infusion |
| Primary | Comparison of the post-DDAVP duration with FVIII normalized above 0.5 IU.dL-1 in patients of the group "Null variants" vs "No Null variants" | Factor VIII levels were measured until 24 hours after the desmopressin infusion | Factor VIII levels measured with a chronometric one stage-assay before and after DDAVP until 24h post-infusion |
| Primary | Comparison of the post-DDAVP duration with FVIII normalized above 0.8 IU.dL-1 in patients of the group "Null variants" vs "No Null variants" | Factor VIII levels were measured until 24 hours after the desmopressin infusion | Factor VIII levels measured with a chronometric one stage-assay before and after DDAVP until 24h post-infusion |
| Secondary | Influence of the age on the post-DDAVP FVIII peak | FVIII levels 30-60 minutes after the DDAVP infusion | factor VIII levels measured with a chronometric one stage-assay 30 or 60 minutes after the DDAVP infusion |
| Secondary | Influence of the age on the post-DDAVP FVIII recovery | FVIII levels before and 30-60 minutes after the DDAVP infusion | Factor VIII levels measured with a chronometric one stage-assay before (basal FVIII) the DDAVP infusion and 30 or 60 minutes after (FVIII peak). The FVIII recovery = ratio FVIII peak / basal FVIII |
| Secondary | influence of the age on the post-DDAVP FVIII area under the curve (AUC) | Factor VIII levels were measured until 24 hours after the desmopressin infusion | Factor VIII levels measured with a chronometric one stage-assay before (basal FVIII) the DDAVP infusion and 30 or 60 minutes after (FVIII peak). The FVIII recovery = ratio FVIII peak / basal FVIII |
| Secondary | influence of the age on the post-DDAVP duration with FVIII normalized above 0.5 IU.dL-1 | Factor VIII levels were measured until 24 hours after the desmopressin infusion | factor VIII levels measured with a chronometric one stage-assay before and after DDAVP until 24h post-infusion |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers10
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06020456
GET https://conductscience.org/api/trials/v1/NCT06020456/registered