Trial · NCT06073665
Dosing of LT4 in Older Individuals
NCT06073665, Phase 4, Recruiting, University of Pennsylvania
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dosing of LT4 in Older Individuals. Trials, record NCT06073665. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06073665
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dosing of LT4 in Older Individuals
- NCT number
- NCT06073665
- Status
- Recruiting
- Phases
- Phase 4
- Enrollment
- 228 participants, estimated
- Lead sponsor
- University of Pennsylvania
- Conditions
- Hypothyroidism
- Interventions
- Levothyroxine Sodium
- First posted
- 2023-10-10
- Last updated
- 2026-02-19
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Thyroid-Related Quality of Life Patient-Reported Outcome Quality of Life scale | 6 months | 22 items, scored 0-100, higher scores indicate worse status |
| Secondary | Thyroid-Related Quality of Life Patient-Reported Outcome Hypothyroidism subscale b. ThyPRO "Tiredness" subscale c. Thyroid Symptoms Questionnaire (TSQ) | 6 months | 4 items, scored 0-100, higher scores indicate worse status |
| Secondary | NIH Toolbox Fluid Cognition Composite Score | 6 months | Adjusted scale score, based around median of 100, higher scores indicated higher function |
| Secondary | Geriatric Depression Scale | 6 months | 30 items, higher scores indicate more depressive symptoms |
| Secondary | Pittsburgh Sleep Quality Index | 6 months | 19 items, range of 0-21, higher scores indicate worse sleep |
| Secondary | Weight | 6 months | kilograms |
| Secondary | LDL cholesterol | 6 months | blood test, g/dL |
| Secondary | Satisfaction with randomized status | 6 months | Participants will be asked if they can guess their randomization status and satisfaction with randomization status |
| Secondary | Beck Anxiety Inventory | 6 months | Beck Anxiety Inventory, 21 items, range 0-63, higher scores indicate more anxiety |
| Secondary | Serum c-telopeptide (CTX) | 6 months | Blood test, pg/mL |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01AG081698 | Levothyroxine Dosing in Older Individuals | CAPPOLA, ANNE R | UNIVERSITY OF PENNSYLVANIA | NATIONAL INSTITUTE ON AGING | 2023 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06073665
GET https://conductscience.org/api/trials/v1/NCT06073665/registered