Trial · NCT06122428
Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye Disease
NCT06122428, Completed, University of Naples
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye Disease. Trials, record NCT06122428. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06122428
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye Disease
- NCT number
- NCT06122428
- Status
- Completed
- Enrollment
- 16 participants, actual
- Lead sponsor
- University of Naples
- Conditions
- Dry Eye Disease
- Interventions
- modified hyaluronic acid 0.1% covalently linked to Riboflavin, hyaluronic acid 0.1%
- First posted
- 2023-11-08
- Last updated
- 2023-11-08
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Evaluate the efficacy and safety of a new 0.1% sodium hyaluronate-riboflavin-conjugated (HAr®) artificial tear in treating ocular discomfort and improving tear film stability in patients with dry eye disease. | From enrollment to the end of treatment at 8 weeks | Ocular discomfort reduction mesured by OSDI test. |
| Secondary | Evaluate the reduction in Tear osmolarity | From enrollment to the end of treatment at 8 weeks | Tear osmolarity test. This measurement provides important information about tear composition. |
| Secondary | Measure the stability of the tear film | From enrollment to the end of treatment at 8 weeks | Tear Break-Up Time (TBUT) test This measures the stability of the tear film. |
| Secondary | Measure the tear production | From enrollment to the end of treatment at 8 weeks | Schirmer test I (without anesthetic) at 5 minutes. This measures tear production. |
| Secondary | Evaluate corneal staining | From enrollment to the end of treatment at 8 weeks | Biomicroscopic observation with white light and cobalt blue light according to the Oxford scheme. It provides information on corneal health. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 39170271 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06122428
GET https://conductscience.org/api/trials/v1/NCT06122428/registered