Trial · NCT06173869
A Randomised Trial Comparing the Ovarian Response of a Starting Dose of Either 10 μg or 15 μg Follitropin Delta (FE 999049) to a Starting Dose of Either 150 IU or 225 IU Follitropin Alfa (GONAL-F) in Conventional Regimens in China
NCT06173869, Phase 3, Completed, Ferring Pharmaceuticals; results first posted 2026-02-12
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Randomised Trial Comparing the Ovarian Response of a Starting Dose of Either 10 μg or 15 μg Follitropin Delta (FE 999049) to a Starting Dose of Either 150 IU or 225 IU Follitropin Alfa (GONAL-F) in Conventional Regimens in China. Trials, record NCT06173869. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06173869
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
A Randomised Trial Comparing the Ovarian Response of a Starting Dose of Either 10 μg or 15 μg Follitropin Delta (FE 999049) to a Starting Dose of Either 150 IU or 225 IU Follitropin Alfa (GONAL-F) in Conventional Regimens in China
- NCT number
- NCT06173869
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 301 participants, actual
- Lead sponsor
- Ferring Pharmaceuticals
- Conditions
- Infertility, Female
- Interventions
- FE 999049, GONAL-F
- First posted
- 2023-12-18
- Last updated
- 2026-02-12
- Results first posted
- 2026-02-12
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Oocytes Retrieved | On day of oocyte retrieval (up to 22 days after start of stimulation) | |
| Secondary | Number of Follicles on Stimulation Day 6 and End-of-stimulation | Stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | |
| Secondary | Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | |
| Secondary | Serum Concentrations of Progesterone on Stimulation Day 6 and End-of-stimulation | stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | |
| Secondary | Number of Fertilised Oocytes | On day 1 after oocyte retrieval (up to 23 days after start of stimulation) | |
| Secondary | Fertilisation Rate | On day 1 after oocyte retrieval (up to 23 days after start of stimulation) | |
| Secondary | Number of Embryos (Total and Quality) | Day 3 after oocyte retrieval | |
| Secondary | Total Gonadotropin Dose | Up to 20 stimulation days | |
| Secondary | Number of Stimulation Days | Up to 20 stimulation days | |
| Secondary | Positive βhCG (Positive Serum βhCG Test 13-15 Days After Transfer) Rate | 13-15 days after transfer |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes16
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Oocytes Retrieved | On day of oocyte retrieval (up to 22 days after start of stimulation) | Oocytes retrieved | MEAN | |
| SECONDARY | Number of Follicles on Stimulation Day 6 and End-of-stimulation | Stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | Follicles | MEAN | |
| SECONDARY | Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | pmol/L | MEAN | |
| SECONDARY | Serum Concentrations of Progesterone on Stimulation Day 6 and End-of-stimulation | stimulation day 6 and end-of-stimulation (maximum stimulation day 20) | nmol/L | MEAN | |
| SECONDARY | Number of Fertilised Oocytes | On day 1 after oocyte retrieval (up to 23 days after start of stimulation) | Fertilised Oocytes | MEAN | |
| SECONDARY | Fertilisation Rate | On day 1 after oocyte retrieval (up to 23 days after start of stimulation) | percentage of fertilised oocytes | MEAN | |
| SECONDARY | Number of Embryos (Total and Quality) | Day 3 after oocyte retrieval | Embryos | MEAN | |
| SECONDARY | Total Gonadotropin Dose | Up to 20 stimulation days | ug | MEAN | |
| SECONDARY | Number of Stimulation Days | Up to 20 stimulation days | days | MEAN | |
| SECONDARY | Positive βhCG (Positive Serum βhCG Test 13-15 Days After Transfer) Rate | 13-15 days after transfer | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 outcomesResults by group52
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Oocytes Retrieved | FE 999049 | 12.7 | Standard Deviation 5.2 | Oocytes retrieved | |
| Number of Oocytes Retrieved | GONAL-F | 11.8 | Standard Deviation 5.3 | Oocytes retrieved | |
| Number of Follicles on Stimulation Day 6 and End-of-stimulation | FE 999049 | Stimulation day 6 | 2.9 | Standard Deviation 3.0 | Follicles |
| Number of Follicles on Stimulation Day 6 and End-of-stimulation | GONAL-F | Stimulation day 6 | 3.0 | Standard Deviation 3.3 | Follicles |
| Number of Follicles on Stimulation Day 6 and End-of-stimulation | FE 999049 | End of stimulation | 13.3 | Standard Deviation 4.4 | Follicles |
| Number of Follicles on Stimulation Day 6 and End-of-stimulation | GONAL-F | End of stimulation | 12.7 | Standard Deviation 4.5 | Follicles |
| Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | FE 999049 | Stimulation day 6 | 1303.2 | Standard Deviation 1093.1 | pmol/L |
| Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | GONAL-F | Stimulation day 6 | 1275.9 | Standard Deviation 1050.8 | pmol/L |
| Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | FE 999049 | End of stimulation | 11181.2 | Standard Deviation 5842.2 | pmol/L |
| Serum Concentrations of Estradiol on Stimulation Day 6 and End-of-stimulation | GONAL-F | End of stimulation | 10124.1 | Standard Deviation 4522.2 | pmol/L |
1 to 10 of 52Source ClinicalTrials.gov
See all 52 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | FE 999049 | 148 | |
| Overall Study | STARTED | GONAL-F | 153 | |
| Overall Study | COMPLETED | FE 999049 | 126 | |
| Overall Study | COMPLETED | GONAL-F | 131 | |
| Overall Study | NOT COMPLETED | FE 999049 | 22 | |
| Overall Study | NOT COMPLETED | GONAL-F | 22 |
Source ClinicalTrials.gov
Adverse events24
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Upper respiratory tract infection | Infections and infestations | FE 999049 | 9 | 148 | 10 |
| other | Upper respiratory tract infection | Infections and infestations | GONAL-F | 5 | 153 | 5 |
| other | Biochemical Pregnancy | Pregnancy, puerperium and perinatal conditions | FE 999049 | 8 | 148 | 8 |
| other | Biochemical Pregnancy | Pregnancy, puerperium and perinatal conditions | GONAL-F | 15 | 153 | 15 |
| other | Abortion Spontaneous | Pregnancy, puerperium and perinatal conditions | FE 999049 | 8 | 148 | 8 |
| other | Abortion Spontaneous | Pregnancy, puerperium and perinatal conditions | GONAL-F | 5 | 153 | 5 |
| other | Morning Sickness | Pregnancy, puerperium and perinatal conditions | FE 999049 | 12 | 148 | 18 |
| other | Morning Sickness | Pregnancy, puerperium and perinatal conditions | GONAL-F | 10 | 153 | 15 |
| other | Hydrometra | Reproductive system and breast disorders | FE 999049 | 9 | 148 | 9 |
| other | Hydrometra | Reproductive system and breast disorders | GONAL-F | 7 | 153 | 8 |
1 to 10 of 24Source ClinicalTrials.gov
See all 24 adverse eventsAdverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | FE 999049 | 0 | 148 |
| Total, all-cause mortality | GONAL-F | 0 | 153 |
| Total, other adverse events | FE 999049 | 16 | 148 |
| Total, other adverse events | GONAL-F | 25 | 153 |
| Total, serious adverse events | FE 999049 | 4 | 148 |
| Total, serious adverse events | GONAL-F | 11 | 153 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| FE 999049 vs GONAL-F: deaths from any cause | Trial comparisons |
| FE 999049 vs GONAL-F: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06173869
GET https://conductscience.org/api/trials/v1/NCT06173869/results?page=2