Trial · NCT06202989
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
NCT06202989, Phase 3, Completed, KAZM Pharmaceuticals Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty. Trials, record NCT06202989. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06202989
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
- NCT number
- NCT06202989
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 306 participants, actual
- Lead sponsor
- KAZM Pharmaceuticals Inc.
- Conditions
- Postsurgical Pain
- Interventions
- Multiprofen-CC™ plus standard treatment, Placebo plus standard treatment
- First posted
- 2024-01-12
- Last updated
- 2026-06-29
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Acute postoperative pain | 1, 2, 3, 4, 5, and 6 weeks postop | Daily pain score on 0-10 numeric rating scale from postop day 1 up to 6 weeks postop. |
| Secondary | Time to opioid cessation | 6 weeks postop | Use of opioids at 6 weeks postop and timing of opioid cessation. |
| Secondary | Cumulative opioid use measured in Morphine Equivalent Dose (MED) | up to 6 weeks postop | Cumulative opioid use up to 6 weeks postop measured in MED |
| Secondary | Weekly Opioid Use | 6 weeks postop | Weekly opioid use over 6 weeks postop, measured as total MED per postoperative week derived from the daily medication diary. |
| Secondary | Satisfaction with Pain Management | 6 weeks postop | Satisfaction with pain management measured on a 0-10 numeric rating scale (NRS; higher score is better). |
| Secondary | Safety - Adverse events | up to 6 weeks postop | Knee-related, surgery-related, and IP or pain medication related AEs, plus all SAEs for 6 weeks postop. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06202989
GET https://conductscience.org/api/trials/v1/NCT06202989/registered