Trial · NCT06243692
Lacosamide Versus Topiramate in Migraine
NCT06243692, Phase 3, Unknown, Kafrelsheikh University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Lacosamide Versus Topiramate in Migraine. Trials, record NCT06243692. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06243692
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Lacosamide Versus Topiramate in Migraine
- NCT number
- NCT06243692
- Status
- Unknown
- Phases
- Phase 3
- Enrollment
- 600 participants, estimated
- Lead sponsor
- Kafrelsheikh University
- Conditions
- Migraine Disorders
- Interventions
- Lacosamide 50 MG, Topiramate 50Mg Tab
- First posted
- 2024-02-06
- Last updated
- 2024-03-29
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The change in migraine days per 28 days | 28 days | The investigators will assess the change in migraine days per 28 days in each group. |
| Secondary | The total number of migraine days after three months of treatment | 3 months | The investigators will assess the total migraine days after three months of regular use of 50 mg lacosamide twice daily and Acetaminophen 500-1000 mg in acute attack or topiramate (100 mg daily) and Acetaminophen 500-1000 mg in acute attack alone. |
| Secondary | The percentage of patients who achieved ≥ 50% reduction in the monthly migraine days frequency compared to the baseline frequency. | 3 months | We will assess The percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency in each group |
| Secondary | HIT-6 score absolute reduction in each group after three months of treatment | 3 months | The investigators assessed the absolute reduction in HIT6 score, the Headache Impact Test-6 (HIT-6) assessed the burden of headache in each group; the HIT-6 consists of six items: pain, social functioning, role functioning, vitality, cognitive functioning, and psychological distress, the patient answers each of the six related questions using one of the following five responses: "never", "rarely", "sometimes", "very often," or "always." These responses are summed to produce a total HIT-6 score that ranges from 36 to 78, where a higher score indicates a greater impact of headache on the daily life of the respondent. It has four impact grades: little-to-no impact (HIT-6 score: 36-49), moderate impact (HIT-6 score: 50-55), substantial impact (HIT-6 score: 56-59), and severe impact (HIT-6 score: 60-78) |
| Secondary | The safety of lacosamide was evaluated by monitoring treatment-emergent adverse events (TEAE) for three months. | 3 months | The safety of treatment was evaluated by monitoring and documenting treatment-emergent adverse events (TEAE) in patients through regular follow-up procedures for three months. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06243692
GET https://conductscience.org/api/trials/v1/NCT06243692/registered