Trial · NCT06256432
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
NCT06256432, Phase 2, Active not recruiting, Noorik Biopharmaceuticals AG
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome. Trials, record NCT06256432. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06256432
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
- NCT number
- NCT06256432
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 54 participants, estimated
- Lead sponsor
- Noorik Biopharmaceuticals AG
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Interventions
- Ambrisentan, Terlipressin
- First posted
- 2024-02-13
- Last updated
- 2026-04-13
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in estimated GFR (eGFR) from baseline | 4 days | As determined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula |
| Secondary | Proportion of patients achieving Hepatorenal Syndrome reversal | 14 days | Reversal defined as two consecutive serum creatinine values \< 1.5 mg/dL (132 µmol/L) within 24 hours |
| Secondary | Proportion of subjects experiencing Hepatorenal Syndrome recurrence | 60 days | Recurrence defined as the appearance of Hepatorenal Syndrome satisfying all clinical trial entry criteria |
| Secondary | Overall survival | 60 days | Proportion of participants alive in each treatment arm |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers9
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06256432
GET https://conductscience.org/api/trials/v1/NCT06256432/registered