Trial · NCT06273397
Acetazolamide or Metolazone in Acute Heart Failure
NCT06273397, Not applicable, Not yet recruiting, Clinica Alemana de Santiago
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Acetazolamide or Metolazone in Acute Heart Failure. Trials, record NCT06273397. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06273397
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Acetazolamide or Metolazone in Acute Heart Failure
- NCT number
- NCT06273397
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 1,050 participants, estimated
- Lead sponsor
- Clinica Alemana de Santiago
- Conditions
- Heart Failure Acute, Decompensated Heart Failure
- Interventions
- Acetazolamide 250 MG, Metolazone 2.5 MG, Furosemide Injection
- First posted
- 2024-02-22
- Last updated
- 2024-03-18
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Treatment success | 4 days | Complete decongestion by the third morning without requiring escalation in diuretic therapy (by the second morning). |
| Secondary | Mortality | 3 months | All-cause mortality during the first 3 months after start of the study |
| Secondary | Worsening Heart Failure | 3 months | Readmission for Heart Failure or Urgent visit for Heart Failure during the first 3 months after start of the study |
| Secondary | Cumulative 24-hour Natriuresis | Day 2 | Natriuresis measured on the second day |
| Secondary | Cumulative weight loss | 4 days | Cumulative weight loss by the third morning |
| Secondary | Subclinical congestion | 4 days | Congestion score will be the score used in the study to evaluate the primary outcome. The calculated scores can range from 0 to 12 points, with 0 indicating absence of congestion and 12 representing the highest degree of congestion. The primary outcome will be defined as achieving a score of 0 or 1 and also having absence of B-lines in the lung ultrasound (negative LUS criterion). In this secondary outcome, the presence of subclinical congestion will be evaluated, which is defined as a congestion score of 0 or 1 but with a positive LUS. |
| Secondary | Change in Hematocrit value | 4 days | Change in Hematocrit |
| Secondary | Change in NT-proBNP concentration | 4 days | Change in NT-proBNP |
| Secondary | Change in CA125 value | 4 days | Change in CA125 |
| Other | Any adverse event | 3 months | Any adverse clinical event related to intervention during the first 3 months after start of the study |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers7
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06273397
GET https://conductscience.org/api/trials/v1/NCT06273397/registered