Trial · NCT06275893
IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy
NCT06275893, Phase 1, Phase 2, Completed, Implicit Bioscience
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy. Trials, record NCT06275893. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06275893
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy
- NCT number
- NCT06275893
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 1 participants, actual
- Lead sponsor
- Implicit Bioscience
- Conditions
- Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Left Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy 1, Arrhythmogenic Cardiomyopathy, ACM, ARVC, PKP2
- Interventions
- IC14
- First posted
- 2024-02-23
- Last updated
- 2026-04-22
Source ClinicalTrials.gov
Registered outcomes20
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Safety: Treatment-emergent adverse events and serious adverse events | Baseline through 14 weeks | Treatment-emergent adverse events and serious adverse events |
| Primary | Safety: Incidence of anti-drug antibodies | Baseline, 4 weeks, and 14 weeks | Incidence of anti-drug antibodies |
| Secondary | Inflammatory biomarker C-reactive protein | Baseline, 12 weeks | Change in concentration from baseline at 12 weeks |
| Secondary | CCR2+ Myocardial Imaging (optional) | Baseline compared to 12 weeks | Mean change in CCR2+ cell myocardial infiltration measured by CCR2+ PET/CT imaging (standardized uptake value) |
| Secondary | Ventricular tachycardia | Baseline compared to 12 weeks | Number of ventricular tachycardia runs in a 7-day Holter monitor |
| Secondary | Ventricular premature contractions | Baseline compared to 12 weeks | Frequency of ventricular premature contractions in a 7-day Holter monitor |
| Secondary | Sustained and non-sustained ventricular tachycardia | Baseline through 12 weeks | Number of episodes of sustained and non-sustained ventricular tachycardia documented by ICD |
| Secondary | Treated ventricular tachycardia | Baseline through 12 weeks | Number of episodes of treated ventricular tachycardia (pacemaker and/or defibrillation) by ICD |
| Secondary | Atrial premature contractions | Baseline compared to 12 weeks | Number of atrial premature contractions in a 7-day Holter monitor |
| Secondary | New York Heart Association (NYHA) Functional Class | Baseline compared to 12 weeks | Change in NYHA Functional Class Questionnaire |
1 to 10 of 20Source ClinicalTrials.gov
See all 20 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06275893
GET https://conductscience.org/api/trials/v1/NCT06275893/registered