Precision Probiotic Supplementation in Individuals With Mild Cognitive Impairment
NCT06278688, Not applicable, Not yet recruiting, National Yang Ming Chiao Tung University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Precision Probiotic Supplementation in Individuals With Mild Cognitive Impairment | ClinicalTrials.gov |
| NCT number | NCT06278688 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 120 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | National Yang Ming Chiao Tung University | ClinicalTrials.gov |
| Conditions | Mild Cognitive Impairment | ClinicalTrials.gov |
| Interventions | Precision probiotics | ClinicalTrials.gov |
| First posted | 2024-02-26 | ClinicalTrials.gov |
| Last updated | 2024-02-26 | ClinicalTrials.gov |
Registered outcomes 5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | The changes in attention | baseline, 3 months, 6 months, 12 months postintervention | The primary outcome measure is the change in standardized scores (z-scores) for attention after 12 months. The average of the standardized scores of forward and backward digit Span subtest, digit symbol substitution subtests and symbol Searching subtest of the Wechsler Adult Intelligence Scale-III (WAIS-3) will represent the score for that domain, with higher scores indicating better performance. | ClinicalTrials.gov |
| Primary | The changes in memory | baseline, 3 months, 6 months, 12 months postintervention | The primary outcome measure is the change in scores for the memory after 12 months. In the memory domain, the Logical Memory subset of the Wechsler Memory Scale (Hua et al., 1997) will be used, with higher scores indicating better performance. | ClinicalTrials.gov |
| Primary | The changes in executive function | baseline, 3 months, 6 months, 12 months postintervention | The primary outcome measure is the change in standardized scores (z-scores) for executive function after 12 months. The average of the standardized scores of the color trails test, stroop color and word test, and verbal fluency test will represent the score for that domain, with higher scores indicating better performance. | ClinicalTrials.gov |
| Secondary | The changes in global cognition at the 12th month from baseline. | baseline, 6months, 12 months postintervention | Mental State Examination measures global cognition and screening tools for cognitive impairment in older, community-dwelling, hospitalized, and institutionalized adults. The education adjusted cut-off was used to indicate impaired global cognition. It has been translated into Chinese for clinical use in Taiwan. It has a maximum score of 30 points, with higher scores indicating better global cognition. | ClinicalTrials.gov |
| Secondary | The changes in brain imaging at the 12th month from baseline. | baseline, 6months, 12 months postintervention | The brain Magnetic Resonance Imaging (MRI) will be performed on a 3-Tesla Magnetom Scanner in the Far-Eastern Memorial Hospital or the Cardinal Tien Hospital. The scanning protocol will consist of the following: whole-brain T1 magnetization-prepared rapid gradient-echo sequence, T2-weighted turbo spin-echo sequence, FLAIR pulse sequence, diffusion tensor imaging, and 6-min resting-state fMRI imaging using gradient-echo echo-planar imaging. During the resting-state fMRI, patients will be told to relax with closed eyes without concentrating on anything particular. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Primary outcome | ConductCognition |
| Short Story Recall | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Verbal Fluency | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)