Trial · NCT06286046
A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy
NCT06286046, Phase 2, Withdrawn, Agios Pharmaceuticals, Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy. Trials, record NCT06286046. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06286046
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy
- NCT number
- NCT06286046
- Status
- Withdrawn
- Phases
- Phase 2
- Enrollment
- 0 participants, actual
- Lead sponsor
- Agios Pharmaceuticals, Inc.
- Conditions
- Sickle Cell Disease, Nephropathy
- Interventions
- Mitapivat
- First posted
- 2024-02-29
- Last updated
- 2026-04-03
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percentage of Participants With Albumin Creatinine Ratio (ACR) Response | Baseline up to 6 months | The ACR response is defined as a decrease of 30% or more in ACR from the baseline to Month 6. |
| Secondary | Change From Baseline in Cystatin C and Creatinine-based Estimated Glomerular Filtration Rate (eGFRcr-cys) | Baseline up to 25 months | |
| Secondary | Change From Baseline in Albumin Creatinine Ratio (ACR) | Baseline up to 25 months | |
| Secondary | Percentage of Participants With Stable ACR | Baseline up to 6 months | Stable ACR is defined as Month 6 ACR within 20% of baseline ACR. |
| Secondary | Annualized Rate of Emergency Room (ER) Visits | Up to 24 months | |
| Secondary | Annualized Rate of Days of Hospitalizations | Up to 24 months | |
| Secondary | Type, Frequency, Severity, and Relationship to Study Drug of Adverse Events (AEs) and Serious Adverse Events (SAEs) | Up to 25 months |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 40569673 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06286046
GET https://conductscience.org/api/trials/v1/NCT06286046/registered