Trial · NCT06299891
Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
NCT06299891, Phase 2, Active not recruiting, Seattle Children's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity. Trials, record NCT06299891. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06299891
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
- NCT number
- NCT06299891
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 24 participants, estimated
- Lead sponsor
- Seattle Children's Hospital
- Conditions
- Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
- Interventions
- Phentermine / Topiramate Extended Release Oral Capsule [Qsymia], Placebo
- First posted
- 2024-03-08
- Last updated
- 2026-10-16
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Treatment-emergent adverse events | From baseline to completion of week 28 | Incidence of treatment-emergent adverse events including any during withdrawal in study drug vs. placebo. |
| Secondary | Maximum tolerated dose | Week 0 to 28 | Maximum tolerated dose achieved by the end of the study in study drug vs. placebo. |
| Secondary | % change in BMI | Week 0 to 28 | % change in BMI in response to study drug vs. placebo. |
| Secondary | Proportion of individuals who experience 5% decrease in BMI | Week 0 to 28 | Proportion of individuals who experience 5% decrease in BMI in response to study drug vs. placebo. |
| Secondary | Proportion of individuals who experience 2.5% decrease in BMI | Week 0 to 28 | Proportion of individuals who experience 2.5% decrease in BMI in response to study drug vs. placebo |
| Secondary | Change in body fat mass | Week 0 to 28 | Change in body fat mass via DXA in response to study drug vs. placebo. |
| Secondary | Change in visceral fat mass | Week 0 to 28 | Change of visceral fat mass in response to study drug vs. placebo via DXA. |
| Secondary | Change in hunger | Week 0 to 28 | Daily assessment of hunger by questionnaire scores will be recorded prior to the patient's first meal of the day. |
| Secondary | Change in energy intake | Week 0 to 28 | Patient's dietary intake via the Automated Self-Administered 24-Hour Dietary Recall. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06299891
GET https://conductscience.org/api/trials/v1/NCT06299891/registered