Trial · NCT06377254
Multi-organ Responses to CHronic Physical Activity and INactivity
NCT06377254, Not applicable, Recruiting, University of Nottingham
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Multi-organ Responses to CHronic Physical Activity and INactivity. Trials, record NCT06377254. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06377254
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Multi-organ Responses to CHronic Physical Activity and INactivity
- NCT number
- NCT06377254
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 40 participants, estimated
- Lead sponsor
- University of Nottingham
- Conditions
- Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline, Age-Related Sarcopenia
- Interventions
- Decreased Physical Activity, Increased Physical activity
- First posted
- 2024-04-22
- Last updated
- 2025-12-04
Source ClinicalTrials.gov
Registered outcomes66
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Cardiorespiratory fitness (VO2 max) | 12 weeks | change in maximal oxygen uptake (continuous incremental bicycle ergometer exercise test with on-line gas analysis) measured every 6 weeks |
| Secondary | Change in Isometric leg strength | 24 weeks | Change in Isometric leg strength measured every 6 weeks using CYBEX dynamometer |
| Secondary | Change in time to leg fatigue | 24 weeks | Change in time taken to induce muscle fatigue measured every 6 weeks using isokinetic knee extensions on a CYBEX dynamometer |
| Secondary | Change in incremental area under the curve (iAUC) for blood glucose concentration | 24 weeks | Change in 180 minute blood glucose concentration incremental area under the curve measured every 6 weeks during an oral glucose tolerance test. |
| Secondary | Change in iAUC for serum insulin concentration | 24 weeks | Change in 180-minute serum insulin concentration incremental area under the curve measured every 6 weeks during an oral glucose tolerance test |
| Secondary | Change in fasting glucose oxidation rate | 24 weeks | Change in glucose oxidation rate (when fasted), measured every 6 weeks using ventilated hood indirect calorimetry |
| Secondary | Change in 'fed' glucose oxidation rate | 24 weeks | Change in glucose oxidation rate (in the insulin-stimulated 'fed' state), measured every 6 weeks using ventilated hood indirect calorimetry during an oral glucose tolerance test |
| Secondary | Change in Short Form Health Survey (SF36) Questionnaire aggregated normalised 'physical' score | 24 weeks | Change in 'SF36' Questionnaire aggregated 'physical' score (normalised to UK population) calculated according to standard procedures (min 0, max 100), with higher score indicating better physical wellbeing measured every 6 weeks |
| Secondary | Change in Short Form Health Survey (SF36) Questionnaire aggregated and normalised 'mental' score | 24 weeks | Change in 'SF36' Questionnaire aggregated 'mental' score (normalised to UK population) calculated according to standard procedures (min 0, max 100), with higher score indicating better mental wellbeing, measured every 6 weeks |
| Secondary | Change in World Health Organisation Quality of Life (WHOQoL) score | 24 weeks | Change in World Health Organisation Quality of Life Score (measured using the WHOQoL-Bref questionnaire every 6 weeks), (min score 0, max 100), with higher score indicating a better state of health. |
1 to 10 of 66Source ClinicalTrials.gov
See all 66 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Arithmetic Fluency Task | Secondary outcome | ConductCognition |
| Choice Reaction Time | Secondary outcome | ConductCognition |
| Corsi Block-Tapping Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06377254
GET https://conductscience.org/api/trials/v1/NCT06377254/registered?page=2