Trial · NCT06401083
The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate
NCT06401083, Phase 4, Recruiting, Semmelweis University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate. Trials, record NCT06401083. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06401083
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate
- NCT number
- NCT06401083
- Status
- Recruiting
- Phases
- Phase 4
- Enrollment
- 226 participants, estimated
- Lead sponsor
- Semmelweis University
- Conditions
- Apnea of Prematurity, Premature Birth, Respiratory Failure
- Interventions
- Caffeine citrate
- First posted
- 2024-05-06
- Last updated
- 2024-05-06
- Other registries' IDs
- eudract:2022-003202-77
Source ClinicalTrials.gov
Registered outcomes19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Rate of extubation failure | 48 hours | Reintubation. The discretion of the attending physician. |
| Secondary | Frequency of apneas | 48 hours | Respiratory failure of 15-20 seconds or shorter duration associated with bradycardia or desaturation. |
| Secondary | Change in the mean heart rate | 72 hours | Mean heart rate measured 24 hours before and 48 hours after intervention. |
| Secondary | Tachycardia | 72 hours | The time interval when the heart rate \>200 (min) during one day (1440 min) in percentage. |
| Secondary | Volume of gastric residuals | 72 hours | Gastric residuals measured 24 hours before and 48 hours after intervention. |
| Secondary | Reduction/Cessation of feeding | 48hours | 48 hours after intervention. |
| Secondary | Change in mean arterial blood pressure | 48 hours | Mean blood pressure measured 24 hours before and after intervention measured with non-invasive methods. |
| Secondary | Mechanical ventilation (MV) days | At discharge from participating centres, an average of one month. | MV days during the length of hospital stay |
| Secondary | Non-invasive ventilation (NIV) days | At discharge from participating centres, an average of one month. | NIV days during the length of hospital stay |
| Secondary | Rate of necrotizing enterocolitis | At discharge from participating centres, an average of one month. | Development of necrotizing enterocolitis according to Bell stages. |
1 to 10 of 19Source ClinicalTrials.gov
See all 19 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers13
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06401083
GET https://conductscience.org/api/trials/v1/NCT06401083/registered