Trial · NCT06408714
Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose
NCT06408714, Phase 3, Withdrawn, University of New Mexico
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose. Trials, record NCT06408714. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06408714
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose
- NCT number
- NCT06408714
- Status
- Withdrawn
- Phases
- Phase 3
- Enrollment
- 0 participants, actual
- Lead sponsor
- University of New Mexico
- Conditions
- Opioid Overdose, Opiate Overdose
- Interventions
- Nalmefene Injection, Naloxone Injection
- First posted
- 2024-05-10
- Last updated
- 2025-02-10
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Recurrent respiratory depression | Within 8 hours of intervention | Recurrent respiratory depression requiring repeat treatment with an opioid antagonist. Respiratory depression is defined as a respiratory rate (RR) \<8 breaths per minute or end-tidal CO2 (ETCO2)\> 50 mm Hg. |
| Secondary | Precipitated withdrawal | Within 8 hours of intervention | • Proportion of subjects experiencing precipitated withdrawal (Clinical Opioid Withdrawal Scale greater than 5 within 20 minutes) after treatment with an opioid antagonist. The Clinical Opioid Withdrawal Scale, or COWS, ranges from 0 to 48, with a higher score signifying worse withdrawal. |
| Secondary | Serious adverse event | Within 8 hours of intervention | • Proportion of subjects experiencing a serious adverse event (likely admission to the hospital, typically for pulmonary edema, methadone overdose, or co-ingestions requiring extended observation). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06408714
GET https://conductscience.org/api/trials/v1/NCT06408714/registered