The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration
NCT06490822, Not applicable, Recruiting, Nantes University Hospital
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration | ClinicalTrials.gov |
| NCT number | NCT06490822 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 80 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Nantes University Hospital | ClinicalTrials.gov |
| Conditions | Frontotemporal Lobar Degeneration | ClinicalTrials.gov |
| Interventions | Skin biopsy | ClinicalTrials.gov |
| First posted | 2024-07-08 | ClinicalTrials.gov |
| Last updated | 2024-12-20 | ClinicalTrials.gov |
Registered outcomes 7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Amount of TDP 43 | Day of inclusion | assessed by Western blot and qPCR to determine level of expression of TDP-43 in the skin | ClinicalTrials.gov |
| Primary | Amount of Tau assessed by Western blot and qPCR | Day of inclusion | assessed by Western blot and qPCR to determine level of expression of Tau in the skin | ClinicalTrials.gov |
| Secondary | Amount of Tau phosphorylation | Day of inclusion | phospho-tau/tau ratio in the skin will be measured by Western blot | ClinicalTrials.gov |
| Secondary | Amount of TDP 43 phosphorylation | Day of inclusion | phospho-TDP-43 /TDP43 ratio in the skin will be measured by Western blot | ClinicalTrials.gov |
| Secondary | Neuropsychological characterization | day of inclusion for patients vFTD, PPA and corticobasal degeneration-CBD and progressive supranuclear palsy-PSP within 12 months of inclusion for patients ALS | During their follow-up FTLD patients underwent a complete neuropsycological assessment define as: * mini-mental state examination (MMSE) * the 16-item Free Recall/Indicated Recall test (RL/RI-16 items) * Rey figure and recall * Trail Making Test (TMT A \& B) * Wechsler Adult Intelligence Scale * Literal (letter P) and categorical (animals) fluency * Rapid Frontal Efficiency Battery (BREF) * Wisconsin Card Sorting Test (WCST) * Zoo test of Behavioural Assessment of the Dysexecutive Syndrome (BADS) * Stroop test - 4 boards * Oral image naming test (DO 80) * Theory of mind (ToM-15) * ekman facial emotion recognition test | ClinicalTrials.gov |
| Secondary | Behaviour profile | day of inclusion for patients vFTD, PPA and corticobasal degeneration-CBD and progressive supranuclear palsy-PSP within 12 months of inclusion for patients ALS | The 10-items scale Daphne will be used to explore disinhibition (4 items), apathy(1 item), perseveration (1 item), hyperorality (2items), personal neglect (1 item) and loss of empathy (1 item) | ClinicalTrials.gov |
| Secondary | FTLD mutation | before inclusion | Mutation carrier patient will be identified among participant (not all the participant) who had a genetic screening had neen carried out during their follow up. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Card Sorting Test (Berg) | Secondary outcome | ConductCognition |
| Emoji Emotion Recognition | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)