Trial · NCT06494904
Standard Versus High Dose ED-Initiated Buprenorphine Induction
NCT06494904, Phase 3, Recruiting, Yale University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Standard Versus High Dose ED-Initiated Buprenorphine Induction. Trials, record NCT06494904. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06494904
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Standard Versus High Dose ED-Initiated Buprenorphine Induction
- NCT number
- NCT06494904
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 360 participants, estimated
- Lead sponsor
- Yale University
- Conditions
- Opioid Use Disorder
- Interventions
- Buprenorphine
- First posted
- 2024-07-10
- Last updated
- 2026-05-28
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Engagement in Treatment (10) | Within 10 days after study randomization | The proportion of patients in each of the two study arms participating in OUD treatment within 10 days after the study randomization |
| Secondary | Craving | Measured daily for 10 days post randomization | The maximum intensity of opioid cravings during the preceding 24 hours assessed daily for 10 days post randomization using a numerical rating scale (0 to 10). |
| Secondary | Withdrawal | Measured daily for 10 days post randomization | The maximum intensity of opioid withdrawal symptoms during the preceding 24 hours assessed daily for 10 days post randomization using a numerical rating scale (0 to 10). |
| Secondary | Substance Use | Measured daily for 10 days post randomization | The number of days with illicit opioid and other substance use based on self-reported data obtained daily during the first 10 days post randomization |
| Secondary | Engagement in Treatment (30) | Within 30 days after randomization | The proportion of patients in each of the two study arms participating in OUD treatment |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 42236100 | DERIVED |
Source PubMed
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| UG1DA015831 | CTN New England Consortium Node | D'ONOFRIO, GAIL; WEISS, ROGER D. | YALE UNIVERSITY | NATIONAL INSTITUTE ON DRUG ABUSE | 2015 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06494904
GET https://conductscience.org/api/trials/v1/NCT06494904/registered