Registered outcomes15

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 15 of 15

List	Outcome	Time frame	Description
Primary	Numeric Rating Scale-11 Smell-Patient Reported Outcome (PRO) (NRS-11-PRO): Improvement	baseline to week 24	Improvement in patient-reported paper diary (scale 0-10). Score of 0="I cannot smell anything", to 10="My sense of smell is normal to me"
Primary	Numeric Rating Scale-11 Taste-Patient Reported Outcome (PRO) (NRS-11-PRO): Improvement	baseline to week 24	Improvement in patient-reported paper diary (scale 0-10). Score of 0="I could not taste food", to 10="My food tastes normal to me"
Primary	Numeric Rating Scale-11 Smell-Patient Reported Outcome (PRO) (NRS-11-PRO): Mean Change	baseline to week 24	Mean Change in patient-reported paper diary (scale 0-10) of sense of smell. Score of 0="I cannot smell anything", to 10="My sense of smell is normal to me"
Primary	Numeric Rating Scale-11 Taste-Patient Reported Outcome (PRO) (NRS-11-PRO): Mean Change	baseline to week 24	Mean Change in patient-reported paper diary (scale 0-10) of ability to taste food. Score of 0="I could not taste food", to 10="My food tastes normal to me"
Secondary	Cumulative Adverse Events (AEs)	baseline to week 24	Cumulative adverse events related to CYR-064
Secondary	Cumulative Serious Adverse Events (SAEs)	baseline to week 24	Cumulative serious adverse events related to CYR-064
Secondary	Cumulative Suspected, Unexpected, Serious Adverse Events Related (SUSARs)	baseline to week 24	Cumulative Suspected, Unexpected, Serious Adverse Events Related to CYR-064
Other	Change in Sniffin' Sticks Threshold, Detection and Identification (TDI) Scores	baseline to week 24	Individual and cumulative scores of odor threshold, detection and identification. Individual scores of odor threshold, detection and identification which are combined for a global score of olfaction. Scores \<16 indicate anosmia, 16-31 indicate hyposmia and \>31 indicate normosmia.
Other	Mean Change in Sniffin' Sticks Threshold, Detection and Identification (TDI) Scores	baseline to week 24	Individual scores of odor threshold, detection and identification which are combined for a global score of olfaction. Scores \<16 indicate anosmia, 16-31 indicate hyposmia and \>31 indicate normosmia.
Other	Numeric Rating Scale-11 Smell-Patient Reported Outcome (PRO) (NRS-11 Smell Impact-PRO Score)	baseline to week 24	Scale of 0-10 of hyposmia: Score of 0="I cannot smell anything", to 10="My sense of smell is normal to me"
Other	Patient Global Impression of Smell Loss Severity (PGI-SLS)	baseline to week 24	Patient's description of loss of sense of smell rated as "I have very severe loss of smell", "I have severe loss of smell", "I have moderate loss of smell", "I have mild loss of smell", "I have no loss of smell"
Other	Patient Global Impression of Smell Loss Change (PGI-SLC)	baseline to week 24	Patient impression of change in sense of smell since starting the study rated as "My sense of smell is much worse now compared to when I started the study", "My sense of smell is worse now compared to when I started the study", "My sense of smell is a little worse compared to when I started the study", "My sense of smell is a little better now compared to when I started the study", "My sense of smell is better now compared to when I started the study", "My sense of smell is much better now compared to when I started the study".
Other	Patient Global Impression of Taste (PGI-T-S)	baseline to week 24	Patient Global Impression of Loss of Ability to Taste Food Severity. Rated as "I have very severe loss of taste", "I have severe loss of taste", "I have moderate loss of taste", "I have mild loss of taste", "I have no loss of taste"
Other	Patient Global Impression of Taste Change (PGI-TC)	baseline to week 24	Patient Global Impression of Change In Ability to Taste Food rated as "My ability to taste food is much worse now compared to when I started the study", "My ability to taste food is worse now compared to when I started the study", "My ability to taste food is a little worse compared to when I started the study", "My ability to taste food is a little better now compared to when I started the study", "My ability to taste food is better now compared to when I started the study", "My ability to taste food is much better now compared to when I started the study".
Other	Correlation of Changes in Numeric Rating Scale-11 Smell-Patient Reported Outcome (PRO) (NRS-11-PRO) Score with Changes in Sniffin' Sticks Threshold Detection and Identification (TDI) Scores	baseline to week 24	Correlation of changes based on patient reported paper diary with clinician administered Sniffin' Sticks

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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