Trial · NCT06518694
Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction
NCT06518694, Phase 3, Recruiting, Assistance Publique - Hôpitaux de Paris
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction. Trials, record NCT06518694. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06518694
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction
- NCT number
- NCT06518694
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 1,300 participants, estimated
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Conditions
- Heart Failure
- Interventions
- Βeta-Blockers discontinued (with tapering)
- First posted
- 2024-07-24
- Last updated
- 2026-01-16
Source ClinicalTrials.gov
Registered outcomes29
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The primary endpoint of the study will be evaluated with one-year minimum follow-up and will be the composite of: | Within 1 year minimum after randomization | \- HF relapse (at any time during the study period): * drop in LVEF \>10% (expressed as absolute value) * relative increase in body surface area-indexed left ventricular end-diastolic volume (LVEDVi) \>10% * increase in NT-proBNP \>2x and ≥ 400 ng/L * worsening heart failure symptoms requiring hospitalization or urgent visits or out-of-hospital therapeutic management with diuretics (intra-venous or oral). |
| Primary | death | Within 1 year minimum after randomization | All-cause death |
| Primary | Hospitalisation for CV reason | Within 1 year minimum after randomization | \- Hospitalisation for CV reason (ACS or need for coronary catheterization +/- revascularization / supra-ventricular arrhythmias / ventricular arrhythmias / Syncope, Pace-Maker implantation / High blood pressure / Stroke). |
| Secondary | HF relapse defined by: | At each visit from randomization through study completion, an average of 4 years | * Reduction in LVEF by more than 10% (absolute value) * A relative increase in LVEDVi by more than 10% * A two-fold rise in baseline NT-pro-BNP concentration and to more than 400 ng/L. * Clinical evidence of heart failure, based on signs and symptoms as adjudicated by the research team. * Hospitalization for worsening HF |
| Secondary | Death | At each visit from randomization through study completion, an average of 4 years | All-cause Death |
| Secondary | All individual reasons for Hospitalisation, as follows: | At each visit from randomization through study completion, an average of 4 years | * ACS or need for coronary catheterisation +/-revascularization * Recurrent ischemia * Supra-ventricular or ventricular arrhythmias * Syncope, PM implantation * High blood pressure * Stroke |
| Secondary | Cardiovascular death | At each visit from randomization through study completion, an average of 4 years | All-cause cardiovascular death |
| Secondary | Number of patients with reduction in LVEF | At each visit from randomization through study completion, an average of 4 years | Number of patients with reduction in LVEF by more than 10% (absolute value) and to less than 50%. |
| Secondary | Number of patients with a relative increase in LVEDVi | At each visit from randomization through study completion, an average of 4 years | Number of patients with a relative increase in LVEDVi by more than 10% and to higher than the normal range. |
| Secondary | Number of patients hospitalized | At each visit from randomization through study completion, an average of 4 years | Number of patients hospitalized for worsening HF |
1 to 10 of 29Source ClinicalTrials.gov
See all 29 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06518694
GET https://conductscience.org/api/trials/v1/NCT06518694/registered?page=2