Trial · NCT06556810
IC14 for Treatment of Acute Decompensated Heart Failure
NCT06556810, Phase 1, Phase 2, Active not recruiting, Implicit Bioscience
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. IC14 for Treatment of Acute Decompensated Heart Failure. Trials, record NCT06556810. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06556810
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- IC14 for Treatment of Acute Decompensated Heart Failure
- NCT number
- NCT06556810
- Status
- Active not recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 10 participants, estimated
- Lead sponsor
- Implicit Bioscience
- Conditions
- Acute Decompensated Heart Failure
- Interventions
- Atibuclimab (IC14)
- First posted
- 2024-08-16
- Last updated
- 2026-03-27
Source ClinicalTrials.gov
Registered outcomes18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Safety of IC14 treatment | 0-28 days | safety measured by treatment-emergent adverse events, including abnormal laboratory values |
| Primary | Anti-Drug Antibodies following IC14 treatment | 0-28 days | anti-drug antibodies |
| Secondary | C-reactive protein, biomarker of inflammation | baseline, 24 hours, 72 hours or discharge, Day 10, Day 29 | area under the curve (0 \[normal\]; 1-10 mg/dL \[moderate elevation\]; \> 10 mg/dL \[marked elevation\] per time) |
| Secondary | B-type natriuretic peptide, biomarker of heart failure | baseline, 24 hours, 72 hours or discharge, Day 10, Day 29 | absolute value (\<100 pg/mL \[normal\], \>=100 pg/mL \[heart failure\]) |
| Secondary | Estimated glomerular filtration rate, biomarker of heart failure | baseline, 72 hours or discharge, Day 10, Day 29 | absolute value(\>=90 ml/min/1.73 m2 \[normal\]; 60-89 \[possible impairment\]; 15-59 \[impairment\]; \<15 \[renal failure\]) |
| Secondary | Urine sodium | baseline, 24 hours, 72 hours or discharge | absolute value (40-220 milliequivalents/day) |
| Secondary | Dyspnea Visual Analogue Scale | baseline, 24 hours, 72 hours, Day 10, Day 29, and 3 months (virtual). | 10-cm Visual Analogue Scale |
| Secondary | Congestion Score | baseline, 24 hours, 72 hours, Day 10, and Day 29 | a composite score of one point for peripheral edema, jugular venous distension ≥10 cm, pulmonary rales, or S3 gallop (0 \[good\] to 4 \[poor\]) |
| Secondary | Loop diuretic requirement | during the first 72 hours of hospitalization | total loop diuretic requirement (in furosemide equivalents) as calculated from concomitant medication listings |
| Secondary | Doppler echocardiogram | baseline, Day 10 | Change from baseline in left ventricular ejection fraction (left ventricular ejection fraction (\>52% male, \>54% female \[normal\]) |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06556810
GET https://conductscience.org/api/trials/v1/NCT06556810/registered