Black Rice Consumption on Cognitive Function, Inflammation and Microvascular Function in Older Adults
NCT06583785, Not applicable, Unknown, University of Reading
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Black Rice Consumption on Cognitive Function, Inflammation and Microvascular Function in Older Adults | ClinicalTrials.gov |
| NCT number | NCT06583785 | ClinicalTrials.gov |
| Status | Unknown | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 24 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Reading | ClinicalTrials.gov |
| Conditions | Older Adults | ClinicalTrials.gov |
| Interventions | Black rice (Intervention), Brown rice (Control) | ClinicalTrials.gov |
| First posted | 2024-09-04 | ClinicalTrials.gov |
| Last updated | 2024-09-04 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Rey Auditory Verbal Learning (RAVLT) | Day 0, 2hrs, Day 7, Day 7-2hrs | This task consists of 5 consecutive free recalls of the same 15 nouns presented as a first auditory list (list A), followed by recall of a further 15 nouns presented as an interference list (list B) which is recalled only once. After 15 words had been presented, participants will be asked to say aloud each word as many as they can recall in any order (approximately a minute). The session will be occurred five times. Then, the participants listen an auditory list of 15 words (list B) and will be asked to say aloud each word as many as they can recall in any order. The number of correct words will be counted and averaged of five trials (list A). Measurements: at baseline (Day 0), acute intervention (2hrs), 7 days short-term intervention (Day 7) and acute on short-term intervention (Day7-2hrs) | ClinicalTrials.gov |
| Primary | Digit span Forward and Backward tasks | Day 0, 2hrs, Day 7, Day 7-2hrs | In this task, the series of digits (numbers) of varying length (spans of 2-9 for forward and 2-8 for backward). It consists of 8 items of forward and 7 items of backward tasks and has 2 trials for each item. The forward and backward digit span tasks, the number will be presented on computer screen an increasingly longer series of digits at a rate of 1 digit/s. The participants will be asked to repeat the number by pressing number on the keyboard. The score will be the maximum of digits of correct both trials, prior to failing two consecutive trials at any one span size. Measurements: at baseline (Day 0), acute intervention (2hrs), 7 days short-term intervention (Day 7) and acute on short-term intervention (Day7-2hrs) | ClinicalTrials.gov |
| Primary | Stroop task | Day 0, 2hrs, Day 7, Day 7-2hrs | The participants were presented with the words 'GREEN', 'BLUE', 'RED' and 'YELLOW', which were displayed either in the same colour ink as the meaning of the word (congruent trials) or in a colour inconsistent with the meaning of the word (incongruent trials). The participant will be instructed to respond to the colour in which the word is presented rather than the meaning of the word, by pressing a corresponding key on the keyboard. There were 96 trials in total and the task lasted for approximately four minutes. The primary dependent variable was reaction time for correct responses. Measurements: at baseline (Day 0), acute intervention (2hrs), 7 days short-term intervention (Day 7) and acute on short-term intervention (Day7-2hrs) | ClinicalTrials.gov |
| Primary | The Digit Symbol-Substitution Task (DSST) | Day 0, 2hrs, Day 7, Day 7-2hrs | Participants are given a table pairing the digits 1 through 9 with nine distinct symbols. Below the table, there is four rows of 25 boxes, each containing a number from one to nine with a blank box underneath. The numbered boxes will be in a random order. Starting at the beginning of the first row and working from left to right down the page, participants will be asked to fill the correct symbol in the blank box using the key at the top of the page. Participants were given 90 seconds to fill in as many boxes as possible in sequential order and the total number of correctly completed boxes will be used to indicate processing speed. Measurements: at baseline (Day 0), acute intervention (2hrs), 7 days short-term intervention (Day 7) and acute on short-term intervention (Day7-2hrs) | ClinicalTrials.gov |
| Secondary | High sensitive C reactive protein (hs-CRP) | Day 0, Day 7 | Serum hs-CRP (mg/L) will be analyzed by automated Enzyme immunoassays (ELISA). | ClinicalTrials.gov |
| Secondary | Serum inflammatory markers | Day 0, Day 7 | All serum inflammatory markers including, IL-6 (pg/ml), IL-1β (pg/ml), and TNF-α (pg/ml) will be analyzed by automated Enzyme immunoassays (ELISA). | ClinicalTrials.gov |
| Secondary | Laser Doppler imaging (LDI) | Day 0, 2hrs, Day 7, Day 7-2hrs | The microvascular blood flow will be measured by LDI technique which assesses the changing of skin blood flow in response to acetylcholine and sodium nitroprusside by iontophoresis. | ClinicalTrials.gov |
| Secondary | Blood pressure (BP) | Day 0, 2hrs, Day 7, Day 7-2hrs | BP (mmHg) will be measeured by Omron BP monitor. | ClinicalTrials.gov |
| Secondary | Heart rate (HR) | Day 0, 2hrs, Day 7, Day 7-2hrs | HP (beat per minute, BPM) will be measeured by Omron BP monitor. | ClinicalTrials.gov |
| Secondary | Vascular cell adhesion protein 1 (VCAM-1) | Day 0, Day 7 | Serum VCAM-1(ng/ml) will be analyzed by automated ELISA. | ClinicalTrials.gov |
| Secondary | Intercellular adhesion molecule-1 (ICAM-1) | Day 0, Day 7 | Serum ICAM-1 (ng/ml) will be analyzed by automated ELISA. | ClinicalTrials.gov |
| Secondary | Brain-derived neurotrophic factor (BDNF) | Day 0, Day 7 | Serum BDNF (pg/ml) will be analyzed by automated ELISA. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 41528201 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Verbal Learning | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)