Trial · NCT06668805
A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment
NCT06668805, Phase 2, Active not recruiting, BioMarin Pharmaceutical
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment. Trials, record NCT06668805. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06668805
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment
- NCT number
- NCT06668805
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- BioMarin Pharmaceutical
- Conditions
- Noonan Syndrome
- Interventions
- Vosoritide Injection
- First posted
- 2024-10-31
- Last updated
- 2026-09-23
Source ClinicalTrials.gov
Registered outcomes35
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from baseline in Annualized Growth Velocity (AGV) | At 6 months | |
| Secondary | Incidence of treatment-emergent adverse events | Until the end of the study, up to 15 years | |
| Secondary | Incidence of new diagnosis of hypertrophic cardiomyopathy in children with Noonan syndrome | Every 12 months through the end of the study, up to 15 years | |
| Secondary | Incidence of cardiac conditions requiring discontinuation of study treatment | Every 12 months through the end of the study, up to 15 years | |
| Secondary | Change from baseline in height | Every 6 months through the end of the study, up to 15 years | |
| Secondary | Change from baseline in height Z-score | Every 6 months through the end of the study, up to 15 years | |
| Secondary | Change from baseline in 12-month interval AGV | Until the end of the study, up to 15 years | |
| Secondary | Change from baseline in upper to lower body segment ratio | Until the end of the study, up to 15 years | |
| Secondary | Change from baseline in arm span to height ratio | Until the end of the study, up to 15 years | |
| Secondary | Change from baseline in height up to Final Adult Height (FAH) | Every 6 months through the end of the study, up to 15 years |
1 to 10 of 35Source ClinicalTrials.gov
See all 35 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06668805
GET https://conductscience.org/api/trials/v1/NCT06668805/registered?page=2